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Literature DB >> 2478394

The selectivity filter of a ligand-gated ion channel. The helix-M2 model of the ion channel of the nicotinic acetylcholine receptor.

Abstract

Evidence from electrophysiology and biochemistry supports the hypothesis that the ion channel of the nicotinic acetylcholine receptor is formed by homologous amino acid sequences of all receptor subunits, called helices M2. A model of the ion channel is proposed and the selectivity filter is described as a ring of negatively-charged amino acid side chains [(1988) Nature 335, 645-648] which may undergo conformational changes upon permeation of the cation.

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Year: 1989 PMID： 2478394 DOI： 10.1016/0014-5793(89)81775-2

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

10 in total

1. A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor.

Authors: Richard J Law; Richard H Henchman; J Andrew McCammon
Journal: Proc Natl Acad Sci U S A Date: 2005-04-27 Impact factor: 11.205

2. Effects of microtubule agents on the spatial and electrical properties of the plasma membrane inChara corallina.

Authors: J Fisahn; W J Lucas
Journal: Planta Date: 1990-11 Impact factor: 4.116

3. The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics.

Authors: R Sankararamakrishnan; C Adcock; M S Sansom
Journal: Biophys J Date: 1996-10 Impact factor: 4.033

4. Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.

Authors: D B Tikhonov; B S Zhorov
Journal: Biophys J Date: 1998-01 Impact factor: 4.033

5. Molecular dynamics study of water and Na+ ions in models of the pore region of the nicotinic acetylcholine receptor.

Authors: G R Smith; M S Sansom
Journal: Biophys J Date: 1997-09 Impact factor: 4.033

6. Attenuation of channel kinetics and conductance by cholesterol: an interpretation using structural stress as a unifying concept.

Authors: H M Chang; R Reitstetter; R P Mason; R Gruener
Journal: J Membr Biol Date: 1995-01 Impact factor: 1.843

The selectivity filter of a ligand-gated ion channel. The helix-M2 model of the ion channel of the nicotinic acetylcholine receptor.

1. A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor.

2. Effects of microtubule agents on the spatial and electrical properties of the plasma membrane inChara corallina.

3. The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics.

4. Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.

5. Molecular dynamics study of water and Na+ ions in models of the pore region of the nicotinic acetylcholine receptor.

6. Attenuation of channel kinetics and conductance by cholesterol: an interpretation using structural stress as a unifying concept.

7. An inhalational anesthetic binding domain in the nicotinic acetylcholine receptor.

8. Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study.

9. The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures.

10. Mechanics of channel gating of the nicotinic acetylcholine receptor.