| Literature DB >> 2478387 |
Abstract
Calcium is released from the isolated heavy sarcoplasmic reticulum (SR) of frog skeletal muscle upon application of 0.1-1 mM diethylpyrocarbonate (DEP, an imidazolyl reagent). The Ca-ATPase activity of SR was suppressed by 20% in the presence of 1 mM DEP. More than 1 mM of free magnesium ion or 5 microM ruthenium red eliminated the effect of DEP on calcium release but not on Ca-ATPase activity. A plausible site of DEP action is on the calcium channel.Entities:
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Year: 1989 PMID： 2478387 DOI： 10.1007/bf01953058
Source DB: PubMed Journal: Experientia ISSN： 0014-4754