Sylvie Hiéronimus1, Patricia Ferrari2, Jocelyn Gal3, Frédéric Berthier3, Stéphane Azoulay4, André Bongain5, Patrick Fénichel6, Françoise Brucker-Davis6. 1. Department of Endocrinology, Diabetology and Reproductive Medicine, University Hospital of Nice, Nice, France. 2. Department of Biochemistry, University Hospital of Nice, Nice, France. 3. Department of Biostatistics, University of Nice, Nice, France. 4. Institute of Chemistry, UMR 6001, University of Nice-Sophia-Antipolis, Nice, France. 5. Department of Gynaecology and Obstetrics, University Hospital of Nice, Nice, France. 6. Department of Endocrinology, Diabetology and Reproductive Medicine, University Hospital of Nice, Nice, France ; Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France.
Abstract
OBJECTIVE: To assess the impact on cord blood (CB) thyroglobulin (Tg) of early iodine supplementation during pregnancy. METHODS: A total of 111 healthy pregnant women with normal thyroid function were included in a prospective randomized study and divided into two groups with (150 μg/day) or without iodine supplementation started during the first trimester. Maternal smoking was assessed qualitatively by self-reported statements and quantitatively by cotininuria. Exhaustive thyroid tests were performed at delivery in the mother and in CB. RESULTS: Third-trimester ioduria documented compliance with iodine supplementation (160 vs. 76 μg/l in controls). CB Tg was not different between the iodine and control groups (median 77 vs. 79.5 ng/ml, respectively) and did not correlate with maternal ioduria. CB Tg was higher in newborns from smoking mothers (114 vs. 64.7 ng/ml) and correlated with self-reported smoking status more than with maternal cotininuria. Nonsmokers had no difference in CB Tg whether they took iodine supplementation or not, as opposed to smokers, who tended to benefit from supplementation. CONCLUSIONS: Iodine supplementation does not significantly impact CB Tg in healthy nonsmoker pregnant women selected for normal thyroid function, as opposed to maternal smoking. CB Tg appears to be a marker of in utero tobacco exposure. In areas of mild iodine deficiency, iodine supplementation could especially benefit the fetuses of smokers.
RCT Entities:
OBJECTIVE: To assess the impact on cord blood (CB) thyroglobulin (Tg) of early iodine supplementation during pregnancy. METHODS: A total of 111 healthy pregnant women with normal thyroid function were included in a prospective randomized study and divided into two groups with (150 μg/day) or without iodine supplementation started during the first trimester. Maternal smoking was assessed qualitatively by self-reported statements and quantitatively by cotininuria. Exhaustive thyroid tests were performed at delivery in the mother and in CB. RESULTS: Third-trimester ioduria documented compliance with iodine supplementation (160 vs. 76 μg/l in controls). CB Tg was not different between the iodine and control groups (median 77 vs. 79.5 ng/ml, respectively) and did not correlate with maternal ioduria. CB Tg was higher in newborns from smoking mothers (114 vs. 64.7 ng/ml) and correlated with self-reported smoking status more than with maternal cotininuria. Nonsmokers had no difference in CB Tg whether they took iodine supplementation or not, as opposed to smokers, who tended to benefit from supplementation. CONCLUSIONS:Iodine supplementation does not significantly impact CB Tg in healthy nonsmoker pregnant women selected for normal thyroid function, as opposed to maternal smoking. CB Tg appears to be a marker of in utero tobacco exposure. In areas of mild iodine deficiency, iodine supplementation could especially benefit the fetuses of smokers.
Authors: Elizabeth N Pearce; Emily Oken; Matthew W Gillman; Stephanie L Lee; Barbarajean Magnani; Deborah Platek; Lewis E Braverman Journal: Endocr Pract Date: 2008 Jan-Feb Impact factor: 3.443
Authors: Marcos Abalovich; Nobuyuki Amino; Linda A Barbour; Rhoda H Cobin; Leslie J De Groot; Daniel Glinoer; Susan J Mandel; Alex Stagnaro-Green Journal: J Clin Endocrinol Metab Date: 2007-08 Impact factor: 5.958
Authors: Sarah D McDonald; Mark C Walker; Arne Ohlsson; Kellie E Murphy; Joseph Beyene; Sherry L Perkins Journal: Eur J Obstet Gynecol Reprod Biol Date: 2008-04-18 Impact factor: 2.435
Authors: Laura Croce; Luca Chiovato; Massimo Tonacchera; Elena Petrosino; Maria Laura Tanda; Mariacarla Moleti; Flavia Magri; Antonella Olivieri; Elizabeth N Pearce; Mario Rotondi Journal: Rev Endocr Metab Disord Date: 2022-10-13 Impact factor: 9.306
Authors: Kimberly B Harding; Juan Pablo Peña-Rosas; Angela C Webster; Constance My Yap; Brian A Payne; Erika Ota; Luz Maria De-Regil Journal: Cochrane Database Syst Rev Date: 2017-03-05
Authors: Monika Katko; Andrea Anett Gazso; Ildiko Hircsu; Harjit Pal Bhattoa; Zsuzsanna Molnar; Bela Kovacs; David Andrasi; Janos Aranyosi; Rita Makai; Lajos Veress; Olga Torok; Miklos Bodor; Laszlo Samson; Endre V Nagy Journal: Matern Child Nutr Date: 2017-06-07 Impact factor: 3.092