Omar Abdul Hameed Ali1, Abdul Fatah Abdul Gadir2. 1. Department of Surgery, University Charity and Teaching Hospital and Khartoum Breast Care Center, Khartoum, Sudan. 2. Department of Pathology, University of Medical Sciences and Technology, Khartoum, Sudan.
Abstract
OBJECTIVES: To report a new phenotype of advanced endemic goiter that affects only one lobe of the thyroid gland. PATIENTS AND METHODS: This study included 60 patients from the west of Sudan with long-standing unilateral simple endemic goiter that required obectomy, with emphasis on the gross appearance, measurements and cytological features of the contralateral lobe. RESULTS: Out of 60 patients with unilateral goiter, 50 (83%) were found to have the disease on the ipsilateral lobe only (monolobar goiter). The contralateral lobe in these 50 patients showed no nodularity, and its volume was within the normal limits. All patients with monolobar disease had total lobectomy on the affected side, and postoperatively they continued to have normal blood levels of T3, T4 and TSH. CONCLUSION: We report a new phenotype of advanced endemic goiter that affects only one lobe of the thyroid gland, and in the presence of a structurally and functionally normal contralateral lobe.
OBJECTIVES: To report a new phenotype of advanced endemic goiter that affects only one lobe of the thyroid gland. PATIENTS AND METHODS: This study included 60 patients from the west of Sudan with long-standing unilateral simple endemic goiter that required obectomy, with emphasis on the gross appearance, measurements and cytological features of the contralateral lobe. RESULTS: Out of 60 patients with unilateral goiter, 50 (83%) were found to have the disease on the ipsilateral lobe only (monolobar goiter). The contralateral lobe in these 50 patients showed no nodularity, and its volume was within the normal limits. All patients with monolobar disease had total lobectomy on the affected side, and postoperatively they continued to have normal blood levels of T3, T4 and TSH. CONCLUSION: We report a new phenotype of advanced endemic goiter that affects only one lobe of the thyroid gland, and in the presence of a structurally and functionally normal contralateral lobe.
Authors: Michael B Zimmermann; Sonja Y Hess; Luciano Molinari; Bruno De Benoist; François Delange; Lewis E Braverman; Kenji Fujieda; Yoshiya Ito; Pieter L Jooste; Khairya Moosa; Elizabeth N Pearce; Eduardo A Pretell; Yoshimasa Shishiba Journal: Am J Clin Nutr Date: 2004-02 Impact factor: 7.045