Pui-Ying Iroh Tam1, Susan Kline, John E Wagner, Amanda Guspiel, Andrew Streifel, Ginger Ward, Keith Messinger, Patricia Ferrieri. 1. From the *Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, University of Minnesota Amplatz Children's Hospital; †Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota; ‡Department of Pediatrics, Division of Pediatric Blood and Marrow Transplantation, University of Minnesota Amplatz Children's Hospital; §University of Minnesota Medical Center, Fairview and University of Minnesota Amplatz Children's Hospital, Minneapolis, MN, USA; ¶Department of Environmental Health; and ‖Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Abstract
BACKGROUND: Rapidly growing mycobacteria (RGM) have a predilection for those with immunocompromised states. We report increased isolation of RGM among pediatric hematopoietic cell transplant patients that was traced to the hospital water supply. METHODS: Cases of RGM-positive patients were differentiated based on whether they were community-acquired or nosocomial, colonized or infected based on predefined criteria. Medical records of all RGM-positive patients were reviewed and data extracted. Infection control outbreak measures were instituted and an environmental investigation was conducted. RESULTS: Between July 2011 and April 2012, 16 RGM isolates were identified among 15 hematopoietic cell transplant patients, compared with none in the preceding year. After environmental samples were initially grown on media for heterotrophic counts and further speciated, RGM species were identified in the hospital water supply. CONCLUSIONS: This outbreak of RGM was traced to an environmental source and was successfully controlled through institution of infection control measures.
BACKGROUND: Rapidly growing mycobacteria (RGM) have a predilection for those with immunocompromised states. We report increased isolation of RGM among pediatric hematopoietic cell transplant patients that was traced to the hospital water supply. METHODS: Cases of RGM-positive patients were differentiated based on whether they were community-acquired or nosocomial, colonized or infected based on predefined criteria. Medical records of all RGM-positive patients were reviewed and data extracted. Infection control outbreak measures were instituted and an environmental investigation was conducted. RESULTS: Between July 2011 and April 2012, 16 RGM isolates were identified among 15 hematopoietic cell transplant patients, compared with none in the preceding year. After environmental samples were initially grown on media for heterotrophic counts and further speciated, RGM species were identified in the hospital water supply. CONCLUSIONS: This outbreak of RGM was traced to an environmental source and was successfully controlled through institution of infection control measures.
Authors: Arthur W Baker; Sarah S Lewis; Barbara D Alexander; Luke F Chen; Richard J Wallace; Barbara A Brown-Elliott; Pamela J Isaacs; Lisa C Pickett; Chetan B Patel; Peter K Smith; John M Reynolds; Jill Engel; Cameron R Wolfe; Carmelo A Milano; Jacob N Schroder; Robert D Davis; Matthew G Hartwig; Jason E Stout; Nancy Strittholt; Eileen K Maziarz; Jennifer Horan Saullo; Kevin C Hazen; Richard J Walczak; Ravikiran Vasireddy; Sruthi Vasireddy; Celeste M McKnight; Deverick J Anderson; Daniel J Sexton Journal: Clin Infect Dis Date: 2017-04-01 Impact factor: 9.079
Authors: Meera Chand; Theresa Lamagni; Katharina Kranzer; Jessica Hedge; Ginny Moore; Simon Parks; Samuel Collins; Carlos Del Ojo Elias; Nada Ahmed; Tim Brown; E Grace Smith; Peter Hoffman; Peter Kirwan; Brendan Mason; Alison Smith-Palmer; Philip Veal; Maeve K Lalor; Allan Bennett; James Walker; Alicia Yeap; Antonio Isidro Carrion Martin; Gayle Dolan; Sonia Bhatt; Andrew Skingsley; André Charlett; David Pearce; Katherine Russell; Simon Kendall; Andrew A Klein; Stephen Robins; Silke Schelenz; William Newsholme; Stephanie Thomas; Tim Collyns; Eleri Davies; Jim McMenamin; Lorraine Doherty; Tim E A Peto; Derrick Crook; Maria Zambon; Nick Phin Journal: Clin Infect Dis Date: 2016-12-07 Impact factor: 20.999