| Literature DB >> 24780903 |
Robert D Stevens1, Yousef Hannawi2, Haris Sair3.
Abstract
Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor tensor imaging studies, these data support of a model of disrupted connectivity as a systems-level approach to the cognitive disturbances seen in SVD.Entities:
Mesh:
Year: 2014 PMID: 24780903 PMCID: PMC4083383 DOI: 10.1038/jcbfm.2014.69
Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN: 0271-678X Impact factor: 6.200