Literature DB >> 24780120

Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata).

Shi Sun1, Jingchun Liu1, Hoda Kadouh1, Xiuxiu Sun1, Kequan Zhou2.   

Abstract

Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and HPLC purification. These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells.
Copyright © 2014. Published by Elsevier Ltd.

Entities:  

Keywords:  Acetogenin; Annona muricata; Cytotoxicity; Human prostate cancer; Muricin

Mesh：

Substances：

Year:  2014        PMID： 24780120     DOI： 10.1016/j.bmcl.2014.03.099

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

Review 1.  Emerging therapeutic potential of graviola and its constituents in cancers.

Authors:  Asif Khurshid Qazi; Jawed A Siddiqui; Rahat Jahan; Sanjib Chaudhary; Larry A Walker; Zafar Sayed; Dwight T Jones; Surinder K Batra; Muzafar A Macha
Journal:  Carcinogenesis       Date:  2018-04-05       Impact factor: 4.944

2.  Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer.

Authors:  Chunhua Yang; Sushma Reddy Gundala; Rao Mukkavilli; Subrahmanyam Vangala; Michelle D Reid; Ritu Aneja
Journal:  Carcinogenesis       Date:  2015-04-11       Impact factor: 4.944

3.  Novel Annonaceous acetogenins from Graviola (Annona muricata) fruits with strong anti-proliferative activity.

Authors:  Shi Sun; Jingchun Liu; Xiuxiu Sun; Wenjun Zhu; Fei Yang; Lisa Felczak; Q Ping Dou; Kequan Zhou
Journal:  Tetrahedron Lett       Date:  2017-04-05       Impact factor: 2.415

Review 4.  Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities.

Authors:  Soheil Zorofchian Moghadamtousi; Mehran Fadaeinasab; Sonia Nikzad; Gokula Mohan; Hapipah Mohd Ali; Habsah Abdul Kadir
Journal:  Int J Mol Sci       Date:  2015-07-10       Impact factor: 5.923

5.  Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad.

Authors:  Yuri N Clement; Varune Mahase; Annelise Jagroop; Kelly Kissoon; Aarti Maharaj; Prashant Mathura; Chrys Mc Quan; Divya Ramadhin; Cherrista Mohammed
Journal:  BMC Complement Altern Med       Date:  2016-10-21       Impact factor: 3.659

6.  Annonaceous acetogenins mediated up-regulation of Notch2 exerts growth inhibition in human gastric cancer cells in vitro.

Authors:  Yan Li; Jianbin Ye; Zhongbiao Chen; Junjie Wen; Fei Li; Pengpeng Su; Yanqing Lin; Bingxin Hu; Danlin Wu; Lijun Ning; Qi Xue; Hongxiang Gu; Yunshan Ning
Journal:  Oncotarget       Date:  2017-03-28

Review 7.  Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents.

Authors:  Siti Mariam Abdul Wahab; Ibrahim Jantan; Md Areeful Haque; Laiba Arshad
Journal:  Front Pharmacol       Date:  2018-06-20       Impact factor: 5.810

8.  Anticancer and Apoptogenic Effect of Graviola and Low-Dose Radiation in Tumor Xenograft in Mice.

Authors:  Ghada A El Tawiil; Eman Ali Noaman; Mostafa A Askar; Neama Mohamed El Fatih; Hebatallah E Mohamed
Journal:  Integr Cancer Ther       Date:  2020 Jan-Dec       Impact factor: 3.279

9.  Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity.

Authors:  Gagan Deep; Rahul Kumar; Anil K Jain; Deepanshi Dhar; Gati K Panigrahi; Anowar Hussain; Chapla Agarwal; Tamam El-Elimat; Vincent P Sica; Nicholas H Oberlies; Rajesh Agarwal
Journal:  Sci Rep       Date:  2016-03-16       Impact factor: 4.379

10.  Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice.

Authors:  Haowen Li; Yijing Li; Hui Ao; Dongdong Bi; Meihua Han; Yifei Guo; Xiangtao Wang
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419
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