Aurelie Cotillard1, Christine Poitou, Adriana Torcivia, Jean-Luc Bouillot, Arne Dietrich, Nora Klöting, Cécile Grégoire, Karine Lolmede, Matthias Blüher, Karine Clément. 1. Sorbonne Universities (A.C., C.P., K.C.), University Pierre et Marie Curie-Paris 6, UMR_S U1166, Nutriomics, F-75013 Paris, France; Institute of Cardiometabolism and Nutrition, ICAN, AP-HP (A.C., C.P., C.G., K.C.), Pitié-Salpêtrière hospital, F-75013 Paris, France; INSERM, UMR_S U1166 (A.C., C.P., K.C.), Nutriomics, F-75013 Paris, France; Assistance Publique-Hôpitaux de Paris (A.T.), Pitié-Salpêtrière hospital, Surgery Department, F-75013 Paris, France; Assistance Publique-Hôpitaux de Paris (J.-L.B.), Ambroise Paré Hospital, Surgery Department, F-92012 Boulogne-Billancourt, France; Department of Surgery (A.D.), University of Leipzig, 04003-04357 Leipzig, Germany; Department of Medicine (N.K., M.B.), University of Leipzig, 04003-04357 Leipzig, Germany; and Junior Research Group Animal Models (N.K.), IFB Obesity Diseases, University of Leipzig, 04003-04357 Leipzig, Germany; AdipoPhyt (K.L.), F-75013 Paris, France.
Abstract
CONTEXT: Adipocyte volume has been associated with insulin resistance and type 2 diabetes. OBJECTIVE: Our purpose was to identify an adipocyte volume threshold linked with increased insulin resistance risk, and to examine its association with insulin resistance improvement after bariatric surgery. SETTING AND DESIGN: We investigated two cohorts of Caucasian women, candidates for bariatric surgery, from two institutional centers in France (age 42.0 ± 11.5 years; body mass index, 47.6 ± 6.9 kg/m(2)) and Germany (age 41.3 ± 11.2 years; body mass index, 49.5 ± 8.1 kg/m(2)). 38% of the subjects had gastric bypass surgery and were followed for 6 months after the intervention. We defined a group of subjects with type 2 diabetes or at risk of type 2 diabetes (DRD) and investigated the relations between adipocyte volume and this status before and after surgery. RESULTS: In both cohorts, subjects with DRD presented enlarged adipocytes (France, P = 3×10(-4); Germany, P =3×10(-10)) and we were able to determine thresholds in each cohort above which diabetes risk was potentially increased (France: 1003±42 pL, Germany: 798±32 pL). Subjects above those adipocyte thresholds were less prone to disappearance of the DRD status after bypass surgery (France, risk ratio = 2.1, P = .024; Germany, risk ratio = 1.3, P = .05). CONCLUSIONS: We show in two cohorts of morbidly obese subjects that a specific adipocyte volume threshold may predict an increased risk for obesity-associated type 2 diabetes. However, this threshold might be established for each specific investigation site. Having a high adipocyte size is associated with a lower improvement of insulin resistance after bypass surgery in both cohorts.
CONTEXT: Adipocyte volume has been associated with insulin resistance and type 2 diabetes. OBJECTIVE: Our purpose was to identify an adipocyte volume threshold linked with increased insulin resistance risk, and to examine its association with insulin resistance improvement after bariatric surgery. SETTING AND DESIGN: We investigated two cohorts of Caucasian women, candidates for bariatric surgery, from two institutional centers in France (age 42.0 ± 11.5 years; body mass index, 47.6 ± 6.9 kg/m(2)) and Germany (age 41.3 ± 11.2 years; body mass index, 49.5 ± 8.1 kg/m(2)). 38% of the subjects had gastric bypass surgery and were followed for 6 months after the intervention. We defined a group of subjects with type 2 diabetes or at risk of type 2 diabetes (DRD) and investigated the relations between adipocyte volume and this status before and after surgery. RESULTS: In both cohorts, subjects with DRD presented enlarged adipocytes (France, P = 3×10(-4); Germany, P =3×10(-10)) and we were able to determine thresholds in each cohort above which diabetes risk was potentially increased (France: 1003±42 pL, Germany: 798±32 pL). Subjects above those adipocyte thresholds were less prone to disappearance of the DRD status after bypass surgery (France, risk ratio = 2.1, P = .024; Germany, risk ratio = 1.3, P = .05). CONCLUSIONS: We show in two cohorts of morbidly obese subjects that a specific adipocyte volume threshold may predict an increased risk for obesity-associated type 2 diabetes. However, this threshold might be established for each specific investigation site. Having a high adipocyte size is associated with a lower improvement of insulin resistance after bypass surgery in both cohorts.
Authors: D Eriksson-Hogling; D P Andersson; J Bäckdahl; J Hoffstedt; S Rössner; A Thorell; E Arner; P Arner; M Rydén Journal: Int J Obes (Lond) Date: 2015-02-10 Impact factor: 5.095
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