Literature DB >> 24779346

What is the risk of aluminium as a neurotoxin?

Christopher Exley1.   

Abstract

Aluminium is neurotoxic. Its free ion, Al(3+) (aq), is highly biologically reactive and uniquely equipped to do damage to essential cellular (neuronal) biochemistry. This unequivocal fact must be the starting point in examining the risk posed by aluminium as a neurotoxin in humans. Aluminium is present in the human brain and it accumulates with age. The most recent research demonstrates that a significant proportion of individuals older than 70 years of age have a potentially pathological accumulation of aluminium somewhere in their brain. What are the symptoms of chronic aluminium intoxication in humans? What if neurodegenerative diseases such as Alzheimer's disease are the manifestation of the risk of aluminium as a neurotoxin? How might such an (outrageous) hypothesis be tested?

Entities:  

Keywords:  Alzheimer’s disease; aluminium; body burden; brain; neurotoxin

Mesh:

Substances:

Year:  2014        PMID: 24779346     DOI: 10.1586/14737175.2014.915745

Source DB:  PubMed          Journal:  Expert Rev Neurother        ISSN: 1473-7175            Impact factor:   4.618


  18 in total

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2.  Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats.

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Journal:  Metab Brain Dis       Date:  2021-01-06       Impact factor: 3.584

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Journal:  Biomater Transl       Date:  2021-09-28

4.  Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats.

Authors:  Jyoti Suryavanshi; Chandra Prakash; Deepak Sharma
Journal:  Metab Brain Dis       Date:  2022-05-13       Impact factor: 3.655

5.  Transcriptome-Wide Identification of Differentially Expressed Genes and Long Non-coding RNAs in Aluminum-Treated Rat Hippocampus.

Authors:  Yirong Xu; Huifang Zhang; Baolong Pan; Shuhui Zhang; Shan Wang; Qiao Niu
Journal:  Neurotox Res       Date:  2018-02-19       Impact factor: 3.911

6.  Bumblebee pupae contain high levels of aluminium.

Authors:  Christopher Exley; Ellen Rotheray; David Goulson
Journal:  PLoS One       Date:  2015-06-04       Impact factor: 3.240

Review 7.  The mobilization of aluminum into the biosphere.

Authors:  Aileen I Pogue; Walter J Lukiw
Journal:  Front Neurol       Date:  2014-12-08       Impact factor: 4.003

Review 8.  Why industry propaganda and political interference cannot disguise the inevitable role played by human exposure to aluminum in neurodegenerative diseases, including Alzheimer's disease.

Authors:  Christopher Exley
Journal:  Front Neurol       Date:  2014-10-27       Impact factor: 4.003

9.  What is the mechanism of formation of hydroxyaluminosilicates?

Authors:  James Beardmore; Xabier Lopez; Jon I Mujika; Christopher Exley
Journal:  Sci Rep       Date:  2016-08-01       Impact factor: 4.379

10.  Aluminium involvement in neurotoxicity.

Authors:  Alessandro Fulgenzi; Daniele Vietti; Maria Elena Ferrero
Journal:  Biomed Res Int       Date:  2014-08-27       Impact factor: 3.411

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