| Literature DB >> 24778035 |
Takashi Oshima1, Kazue Yoshihara, Toru Aoyama, Shinich Hasegawa, Tsutomu Sato, Naoto Yamamoto, Nozaki Akito, Manabu Shiozawa, Takaki Yoshikawa, Kazushi Numata, Yasushi Rino, Chikara Kunisaki, Katsuaki Tanaka, Makoto Akaike, Toshio Imada, Munetaka Masuda.
Abstract
Inhibin-βA (INHBA), a ligand belonging to the transforming growth factor-β superfamily, is associated with cell proliferation in cancer. We studied the relations of INHBA gene expression to clinicopathological factors and outcomes in 168 patients with gastric cancer who underwent curative surgery. Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction. INHBA expression levels were significantly higher in cancer tissue than in adjacent normal mucosa and were related to TNM stage and venous invasion. High INHBA gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, INHBA gene expression was an independent prognostic factor. Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery.Entities:
Keywords: Inhibin beta A; gastric cancer; prognostic factor
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Year: 2014 PMID： 24778035
Source DB: PubMed Journal: Anticancer Res ISSN： 0250-7005 Impact factor: 2.480