Andrés Labiano-Fontcuberta1, Alex J Mitchell2, Sara Moreno-García1, Julián Benito-León3. 1. University Hospital "12 de Octubre", Spain. 2. Leicestershire Partnership Trust and University of Leicester, UK. 3. University Hospital "12 de Octubre", Spain/Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain/Complutense University, Spain jbenitol67@gmail.com.
Abstract
BACKGROUND: Little information exists about how cognitive impairment in multiple sclerosis (MS) patients impacts on their caregivers' health-related quality of life (HRQoL). BACKGROUND: The objective of this paper is to examine the extent to which cognitive impairment in MS patients contributes to caregivers' HRQoL. METHODS: A total of 63 MS patients, 63 caregivers and 59 matched controls were recruited. Patients and controls underwent a neuropsychological assessment, including tests of working memory, speed of information processing, executive function, and verbal fluency. HRQoL of the caregivers was assessed by CAREQOL-MS. In logistic regression models, we adjusted for the effects of confounding variables. In these models, the dependent variable was the CAREQOL-MS (higher median of CAREQOL-MS (worse HRQoL) vs. lower median of CAREQOL-MS (better HRQoL) (reference)), and the independent variable was the impairment on each neuropsychological test vs. its integrity (reference). RESULTS: Cognitive impairment in MS patients was significantly associated with worse caregiver HRQoL (adjusted odds ratio (OR) = 3.10, 95% confidence interval (CI) = 1.07-11.55, p = 0.04). In secondary analyses in which each neuropsychological test was entered in the analyses separately, only Symbol Digit Modalities Test (a measurement of information processing speed) impairment (OR = 4.22, 95%, CI = 1.16-14.53, p = 0.03) was significantly associated with worse caregiver HRQoL. CONCLUSIONS: MS patients' caregivers' HRQoL is significantly influenced by information processing speed impairment of MS patients.
BACKGROUND: Little information exists about how cognitive impairment in multiple sclerosis (MS) patients impacts on their caregivers' health-related quality of life (HRQoL). BACKGROUND: The objective of this paper is to examine the extent to which cognitive impairment in MSpatients contributes to caregivers' HRQoL. METHODS: A total of 63 MSpatients, 63 caregivers and 59 matched controls were recruited. Patients and controls underwent a neuropsychological assessment, including tests of working memory, speed of information processing, executive function, and verbal fluency. HRQoL of the caregivers was assessed by CAREQOL-MS. In logistic regression models, we adjusted for the effects of confounding variables. In these models, the dependent variable was the CAREQOL-MS (higher median of CAREQOL-MS (worse HRQoL) vs. lower median of CAREQOL-MS (better HRQoL) (reference)), and the independent variable was the impairment on each neuropsychological test vs. its integrity (reference). RESULTS:Cognitive impairment in MSpatients was significantly associated with worse caregiver HRQoL (adjusted odds ratio (OR) = 3.10, 95% confidence interval (CI) = 1.07-11.55, p = 0.04). In secondary analyses in which each neuropsychological test was entered in the analyses separately, only Symbol Digit Modalities Test (a measurement of information processing speed) impairment (OR = 4.22, 95%, CI = 1.16-14.53, p = 0.03) was significantly associated with worse caregiver HRQoL. CONCLUSIONS:MSpatients' caregivers' HRQoL is significantly influenced by information processing speed impairment of MSpatients.
Authors: Jack Cotter; Nethmi Vithanage; Shuna Colville; Dawn Lyle; Denise Cranley; Francesca Cormack; Jennifer H Barnett; Katy Murray; Suvankar Pal Journal: Front Neurol Date: 2018-05-11 Impact factor: 4.003
Authors: Jose M García-Domínguez; María L Martínez-Ginés; Olga Carmona; Ana B Caminero; Daniel Prefasi; Jorge Maurino; Javier Ballesteros Journal: Patient Prefer Adherence Date: 2019-01-09 Impact factor: 2.711