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Literature DB >> 24777251

'Lnc'-ing enhancers to MYC regulation.

Abstract

Long noncoding RNAs (lncRNAs) are emerging as important functional components in the establishment of long-range chromosomal interactions. In a recent paper published in Cell Research, Xiang et al. provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L, a colorectal cancer-specific lncRNA, in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.

Entities: Disease Gene

Mesh：

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Year: 2014 PMID： 24777251 PMCID： PMC4042177 DOI： 10.1038/cr.2014.54

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

11 in total

1. Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

Authors: Frederic Koch; Romain Fenouil; Marta Gut; Pierre Cauchy; Thomas K Albert; Joaquin Zacarias-Cabeza; Salvatore Spicuglia; Albane Lamy de la Chapelle; Martin Heidemann; Corinna Hintermair; Dirk Eick; Ivo Gut; Pierre Ferrier; Jean-Christophe Andrau
Journal: Nat Struct Mol Biol Date: 2011-07-17 Impact factor: 15.369

2. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.

Authors: Kevin C Wang; Yul W Yang; Bo Liu; Amartya Sanyal; Ryan Corces-Zimmerman; Yong Chen; Bryan R Lajoie; Angeline Protacio; Ryan A Flynn; Rajnish A Gupta; Joanna Wysocka; Ming Lei; Job Dekker; Jill A Helms; Howard Y Chang
Journal: Nature Date: 2011-03-20 Impact factor: 49.962

3. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.

Authors: Jesse M Engreitz; Amy Pandya-Jones; Patrick McDonel; Alexander Shishkin; Klara Sirokman; Christine Surka; Sabah Kadri; Jeffrey Xing; Alon Goren; Eric S Lander; Kathrin Plath; Mitchell Guttman
Journal: Science Date: 2013-07-04 Impact factor: 47.728

4. Long noncoding RNAs with enhancer-like function in human cells.

Authors: Ulf Andersson Ørom; Thomas Derrien; Malte Beringer; Kiranmai Gumireddy; Alessandro Gardini; Giovanni Bussotti; Fan Lai; Matthias Zytnicki; Cedric Notredame; Qihong Huang; Roderic Guigo; Ramin Shiekhattar
Journal: Cell Date: 2010-10-01 Impact factor: 41.582

5. A misplaced lncRNA causes brachydactyly in humans.

Authors: Philipp G Maass; Andreas Rump; Herbert Schulz; Sigmar Stricker; Lisanne Schulze; Konrad Platzer; Atakan Aydin; Sigrid Tinschert; Mary B Goldring; Friedrich C Luft; Sylvia Bähring
Journal: J Clin Invest Date: 2012-10-24 Impact factor: 14.808

6. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.

Authors: Ezgi Hacisuleyman; Loyal A Goff; Cole Trapnell; Adam Williams; Jorge Henao-Mejia; Lei Sun; Patrick McClanahan; David G Hendrickson; Martin Sauvageau; David R Kelley; Michael Morse; Jesse Engreitz; Eric S Lander; Mitch Guttman; Harvey F Lodish; Richard Flavell; Arjun Raj; John L Rinn
Journal: Nat Struct Mol Biol Date: 2014-01-26 Impact factor: 15.369

7. A large fraction of extragenic RNA pol II transcription sites overlap enhancers.

Authors: Francesca De Santa; Iros Barozzi; Flore Mietton; Serena Ghisletti; Sara Polletti; Betsabeh Khoramian Tusi; Heiko Muller; Jiannis Ragoussis; Chia-Lin Wei; Gioacchino Natoli
Journal: PLoS Biol Date: 2010-05-11 Impact factor: 8.029

8. Widespread transcription at neuronal activity-regulated enhancers.

Authors: Tae-Kyung Kim; Martin Hemberg; Jesse M Gray; Allen M Costa; Daniel M Bear; Jing Wu; David A Harmin; Mike Laptewicz; Kellie Barbara-Haley; Scott Kuersten; Eirene Markenscoff-Papadimitriou; Dietmar Kuhl; Haruhiko Bito; Paul F Worley; Gabriel Kreiman; Michael E Greenberg
Journal: Nature Date: 2010-04-14 Impact factor: 49.962

'Lnc'-ing enhancers to MYC regulation.

1. Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

2. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.

3. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.

4. Long noncoding RNAs with enhancer-like function in human cells.

5. A misplaced lncRNA causes brachydactyly in humans.

6. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.

7. A large fraction of extragenic RNA pol II transcription sites overlap enhancers.

8. Widespread transcription at neuronal activity-regulated enhancers.

9. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus.

10. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation.

1. CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.

2. Mechanism of long noncoding RNAs as transcriptional regulators in cancer.

Review 3. Diagnostic, prognostic and therapeutic potential of long noncoding RNAs in cancer.

Review 4. CCAT1: a pivotal oncogenic long non-coding RNA in human cancers.

5. A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma.

Review 6. Long non-coding RNAs: a rising biotarget in colorectal cancer.

Review 7. Long noncoding RNAs: Undeciphered cellular codes encrypting keys of colorectal cancer pathogenesis.

Review 8. Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer.

Review 9. Current Advances on the Important Roles of Enhancer RNAs in Molecular Pathways of Cancer.

10. CCAT-1 promotes proliferation and inhibits apoptosis of cervical cancer cells via the Wnt signaling pathway.