Literature DB >> 24777094

Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis.

Freda E-C Jen1, Kate L Seib1, Michael P Jennings2.   

Abstract

Phase variation is a common feature of host-adapted bacterial pathogens such as Neisseria meningitidis. Recently, we reported that this rapid on/off switching of gene expression occurs in DNA methyltransferases, altering expression in multiple genes via changes in global methylation. In the current study, we compared MIC values of strains with ModA11, ModA12, and ModD1 phasevarions, revealing MIC differences due to ModA11 and ModA12 switching, with a ModA11_OFF strain showing 4-fold reduced susceptibilities to ceftazidime and ciprofloxacin.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24777094      PMCID： PMC4068601          DOI： 10.1128/AAC.00004-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  International clone of Neisseria meningitidis serogroup A with tetracycline resistance due to tet(B).

Authors:  Sharon A Crawford; Kristin R Fiebelkorn; Jan E Patterson; James H Jorgensen
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

2.  Susceptibility of Neisseria meningitidis to 16 antimicrobial agents and characterization of resistance mechanisms affecting some agents.

Authors:  James H Jorgensen; Sharon A Crawford; Kristin R Fiebelkorn
Journal:  J Clin Microbiol       Date:  2005-07       Impact factor: 5.948

3.  Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility.

Authors:  Ian R Peak; Courtney D Jennings; Freda E-C Jen; Michael P Jennings
Journal:  Antimicrob Agents Chemother       Date:  2013-10-21       Impact factor: 5.191

Review 4.  The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes.

Authors:  Yogitha N Srikhanta; Kate L Fox; Michael P Jennings
Journal:  Nat Rev Microbiol       Date:  2010-02-08       Impact factor: 60.633

5.  A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.

Authors:  Kate L Seib; Eva Pigozzi; Alessandro Muzzi; Jayde A Gawthorne; Isabel Delany; Michael P Jennings; Rino Rappuoli
Journal:  FASEB J       Date:  2011-06-16       Impact factor: 5.191

Review 6.  N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.

Authors:  Didier Wion; Josep Casadesús
Journal:  Nat Rev Microbiol       Date:  2006-03       Impact factor: 60.633

7.  Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America.

Authors:  Henry M Wu; Brian H Harcourt; Cynthia P Hatcher; Stanley C Wei; Ryan T Novak; Xin Wang; Billie A Juni; Anita Glennen; David J Boxrud; Jean Rainbow; Susanna Schmink; Raydel D Mair; M Jordan Theodore; Molly A Sander; Tracy K Miller; Kirby Kruger; Amanda C Cohn; Thomas A Clark; Nancy E Messonnier; Leonard W Mayer; Ruth Lynfield
Journal:  N Engl J Med       Date:  2009-02-26       Impact factor: 91.245

8.  Ciprofloxacin-resistant Neisseria meningitidis, Delhi, India.

Authors:  Smita Singhal; Kedar P Purnapatre; Vandana Kalia; Smita Dube; Deepti Nair; Monorama Deb; Pushpa Aggarwal; Sunil Gupta; Dilip J Upadhyay; Ashok Rattan; V Samuel Raj
Journal:  Emerg Infect Dis       Date:  2007-10       Impact factor: 6.883

9.  Ciprofloxacin resistance in Neisseria meningitidis, France.

Authors:  Anna Skoczynska; Jean-Michel Alonso; Muhamed-Kheir Taha
Journal:  Emerg Infect Dis       Date:  2008-08       Impact factor: 6.883

10.  Phasevarions mediate random switching of gene expression in pathogenic Neisseria.

Authors:  Yogitha N Srikhanta; Stefanie J Dowideit; Jennifer L Edwards; Megan L Falsetta; Hsing-Ju Wu; Odile B Harrison; Kate L Fox; Kate L Seib; Tina L Maguire; Andrew H-J Wang; Martin C Maiden; Sean M Grimmond; Michael A Apicella; Michael P Jennings
Journal:  PLoS Pathog       Date:  2009-04-24       Impact factor: 6.823
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  18 in total

Review 1.  Prokaryotic DNA methylation and its functional roles.

Authors:  Hoon Je Seong; Sang-Wook Han; Woo Jun Sul
Journal:  J Microbiol       Date:  2021-02-23       Impact factor: 3.422

Review 2.  Neisseria gonorrhoeae host adaptation and pathogenesis.

Authors:  Sarah Jane Quillin; H Steven Seifert
Journal:  Nat Rev Microbiol       Date:  2018-02-12       Impact factor: 60.633

Review 3.  Antibiotic Resistance and Epigenetics: More to It than Meets the Eye.

Authors:  Dipannita Ghosh; Balaji Veeraraghavan; Ravikrishnan Elangovan; Perumal Vivekanandan
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

Review 4.  Deciphering bacterial epigenomes using modern sequencing technologies.

Authors:  John Beaulaurier; Eric E Schadt; Gang Fang
Journal:  Nat Rev Genet       Date:  2019-03       Impact factor: 53.242

Review 5.  Novel Identification of Bacterial Epigenetic Regulations Would Benefit From a Better Exploitation of Methylomic Data.

Authors:  Amaury Payelleville; Julien Brillard
Journal:  Front Microbiol       Date:  2021-05-14       Impact factor: 5.640

6.  Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes.

Authors:  John Beaulaurier; Xue-Song Zhang; Shijia Zhu; Robert Sebra; Chaggai Rosenbluh; Gintaras Deikus; Nan Shen; Diana Munera; Matthew K Waldor; Andrew Chess; Martin J Blaser; Eric E Schadt; Gang Fang
Journal:  Nat Commun       Date:  2015-06-15       Impact factor: 14.919

7.  Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.

Authors:  Aimee Tan; Dorothea M C Hill; Odile B Harrison; Yogitha N Srikhanta; Michael P Jennings; Martin C J Maiden; Kate L Seib
Journal:  Sci Rep       Date:  2016-02-12       Impact factor: 4.379

8.  Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis.

Authors:  Kate L Seib; Freda E-C Jen; Aimee Tan; Adeana L Scott; Ritesh Kumar; Peter M Power; Li-Tzu Chen; Hsing-Ju Wu; Andrew H-J Wang; Dorothea M C Hill; Yvette A Luyten; Richard D Morgan; Richard J Roberts; Martin C J Maiden; Matthew Boitano; Tyson A Clark; Jonas Korlach; Desirazu N Rao; Michael P Jennings
Journal:  Nucleic Acids Res       Date:  2015-04-06       Impact factor: 16.971

9.  In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.

Authors:  Emilio Siena; Romina D'Aurizio; David Riley; Hervé Tettelin; Silvia Guidotti; Giulia Torricelli; E Richard Moxon; Duccio Medini
Journal:  BMC Genomics       Date:  2016-10-28       Impact factor: 3.969

10.  A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Authors:  John M Atack; Yogitha N Srikhanta; Kate L Fox; Joseph A Jurcisek; Kenneth L Brockman; Tyson A Clark; Matthew Boitano; Peter M Power; Freda E-C Jen; Alastair G McEwan; Sean M Grimmond; Arnold L Smith; Stephen J Barenkamp; Jonas Korlach; Lauren O Bakaletz; Michael P Jennings
Journal:  Nat Commun       Date:  2015-07-28       Impact factor: 14.919
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