Literature DB >> 24777077

Herpes zoster encephalopathy or acyclovir neurotoxicity: a management dilemma.

Daniel Sacchetti1, Aydah Alawadhi, Mustafa Albakour, Alwyn Rapose.   

Abstract

This is a case report of a 69-year-old morbidly obese woman who presented with mental status changes after she was treated with acyclovir for shingles. The predominant symptoms were word-finding difficulties and visual hallucinations. Complicating her presentation was acyclovir-induced acute renal injury causing her creatinine level to rise up to 7.4 mg/dL. Acyclovir was discontinued on the suspicion of acyclovir neurotoxicity. Even though PCR for varicella zoster virus in the cerebrospinal fluid was positive, acyclovir was not restarted and the patient continued to improve and returned to her baseline.

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Year:  2014        PMID： 24777077      PMCID： PMC4009849          DOI： 10.1136/bcr-2013-201941

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  14 in total

1.  Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite.

Authors:  Patrina Gunness; Katarina Aleksa; John Bend; Gideon Koren
Journal:  Transl Res       Date:  2011-08-03       Impact factor: 7.012

Review 2.  Recommendations for the management of herpes zoster.

Authors:  Robert H Dworkin; Robert W Johnson; Judith Breuer; John W Gnann; Myron J Levin; Miroslav Backonja; Robert F Betts; Anne A Gershon; Maija L Haanpaa; Michael W McKendrick; Turo J Nurmikko; Anne Louise Oaklander; Michael N Oxman; Deborah Pavan-Langston; Karin L Petersen; Michael C Rowbotham; Kenneth E Schmader; Brett R Stacey; Stephen K Tyring; Albert J M van Wijck; Mark S Wallace; Sawko W Wassilew; Richard J Whitley
Journal:  Clin Infect Dis       Date:  2007-01-01       Impact factor: 9.079

3.  Aciclovir neurotoxicity is an important side effect of therapy in patients with renal impairment.

Authors:  Mark Brady; John Main
Journal:  Clin Med (Lond)       Date:  2009-12       Impact factor: 2.659

4.  Neuropsychiatric toxicity in a patient undergoing hemodialysis and receiving treatment with oral acyclovir.

Authors:  A Collins; D Krieff; C Smith; C Singer
Journal:  Clin Infect Dis       Date:  1996-01       Impact factor: 9.079

5.  Neurological toxicity of acyclovir: report of a case in a six-month-old liver transplant recipient.

Authors:  L Chevret; D Debray; C Poulain; Ph Durand; D Devictor
Journal:  Pediatr Transplant       Date:  2006-08

6.  Etiology of aseptic meningitis and encephalitis in an adult population.

Authors:  L Kupila; T Vuorinen; R Vainionpää; V Hukkanen; R J Marttila; P Kotilainen
Journal:  Neurology       Date:  2006-01-10       Impact factor: 9.910

7.  Infections of the central nervous system of suspected viral origin: a collaborative study from Finland.

Authors:  M Koskiniemi; T Rantalaiho; H Piiparinen; C H von Bonsdorff; M Färkkilä; A Järvinen; E Kinnunen; S Koskiniemi; L Mannonen; M Muttilainen; K Linnavuori; J Porras; M Puolakkainen; K Räihä; E M Salonen; P Ukkonen; A Vaheri; V Valtonen
Journal:  J Neurovirol       Date:  2001-10       Impact factor: 2.643

Review 8.  Clinical practice: Herpes zoster.

Authors:  Jeffrey I Cohen
Journal:  N Engl J Med       Date:  2013-07-18       Impact factor: 91.245

9.  Acyclovir-induced neuropsychosis successfully recovered after immediate hemodialysis in an end-stage renal disease patient.

Authors:  Hung-Hsu Yang; Yu-Ping Hsiao; Hung-Chun Shih; Jen-Hung Yang
Journal:  Int J Dermatol       Date:  2007-08       Impact factor: 2.736

10.  Coma secondary to aciclovir neurotoxicity.

Authors:  J Loughrey; P Coleman; J Donohue; B Marsh
Journal:  Ir J Med Sci       Date:  2001 Jan-Mar       Impact factor: 2.089
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  5 in total

1.  Orbital apex syndrome and meningoencephalitis: a rare complication of herpes zoster.

Authors:  Zheman Xiao; Zuneng Lu; Songqing Pan; Jingjing Liang; Zhongchun Liu
Journal:  Int J Clin Exp Med       Date:  2015-08-15

Review 2.  Acyclovir-induced neurotoxicity with a positive cerebrospinal fluid varicella zoster PCR result creating a management dilemma: a case report.

Authors:  Kelli M Robertson; Christopher L Harvey; John M Cunningham
Journal:  J Med Case Rep       Date:  2020-09-18

3.  Encephalopathy Induced by Preventive Administration of Acyclovir in a Man with Symptomatic Multiple Myeloma and Renal Dysfunction.

Authors:  Kazuma Sugimoto; Tsuneaki Kenzaka; Ryu Sugimoto; Akihito Kitao; Hozuka Akita
Journal:  Int J Gen Med       Date:  2021-02-11

Review 4.  Acute kidney injury and acyclovir-associated encephalopathy after administration of valacyclovir in an elderly person with normal renal function: A case report and literature review.

Authors:  Tsuneaki Kenzaka; Kazuma Sugimoto; Ken Goda; Hozuka Akita
Journal:  Medicine (Baltimore)       Date:  2021-05-28       Impact factor: 1.817

5.  Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir.

Authors:  Martin Gnoni; Kamran Zaheer; Melinda M Vasser; Monider Singh; Aman Ajmeri; Stephanie R Harter; Abdul Mughees Rana; Rodrigo Aguilar
Journal:  IDCases       Date:  2018-08-25
  5 in total

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