BACKGROUND: Uveal melanoma (UM) is a rare disease characterized by an unpredictable course and a variable outcome. We assessed the natural course of patients with metastatic uveal melanoma (MUM). METHODS: Data from 76 patients with MUM who were treated in Leuven between 1957 and 2008 were examined retrospectively. Statistical analysis involved the nonparametric, Kaplan-Meier and log rank tests. RESULTS: The median age at diagnosis of UM was 58 years (range 30-94). Synchronous metastases were found in 9% of the cases; all other patients had metachronous disease after a median interval of 40 months (range 7-420). Statistical analysis failed to identify factors related to the time until metastatic spread with the exception of a significant negative correlation with age at UM diagnosis (Spearman: ρ = -0.4, p < 0.001). The most frequent metastatic site was the liver (in 96% of the patients). The median time from diagnosis of UM until death was 47 months (range 2-236) and only 5 months in patients with metastatic disease (range 1-128). CONCLUSIONS: MUM is an orphan disease. Advances in MUM can only be achieved by the networking of sites interested in this rare tumor type, with systematic collection of data and tumor tissue for improving our understanding of the molecular biology of this disease.
BACKGROUND:Uveal melanoma (UM) is a rare disease characterized by an unpredictable course and a variable outcome. We assessed the natural course of patients with metastatic uveal melanoma (MUM). METHODS: Data from 76 patients with MUM who were treated in Leuven between 1957 and 2008 were examined retrospectively. Statistical analysis involved the nonparametric, Kaplan-Meier and log rank tests. RESULTS: The median age at diagnosis of UM was 58 years (range 30-94). Synchronous metastases were found in 9% of the cases; all other patients had metachronous disease after a median interval of 40 months (range 7-420). Statistical analysis failed to identify factors related to the time until metastatic spread with the exception of a significant negative correlation with age at UM diagnosis (Spearman: ρ = -0.4, p < 0.001). The most frequent metastatic site was the liver (in 96% of the patients). The median time from diagnosis of UM until death was 47 months (range 2-236) and only 5 months in patients with metastatic disease (range 1-128). CONCLUSIONS: MUM is an orphan disease. Advances in MUM can only be achieved by the networking of sites interested in this rare tumor type, with systematic collection of data and tumor tissue for improving our understanding of the molecular biology of this disease.
Authors: Alexander N Shoushtari; Leonard T Ong; Heiko Schoder; Shahnaz Singh-Kandah; Kelly T Abbate; Michael A Postow; Margaret K Callahan; Jedd Wolchok; Paul B Chapman; Katherine S Panageas; Gary K Schwartz; Richard D Carvajal Journal: Melanoma Res Date: 2016-06 Impact factor: 3.599
Authors: Lindsay K Klofas; Carley M Bogan; Alice C Coogan; Stephen J Schultenover; Vivian L Weiss; Anthony B Daniels Journal: Am J Ophthalmol Date: 2020-08-18 Impact factor: 5.258
Authors: Gaurav Garg; Paul T Finger; Tero T Kivelä; E Rand Simpson; Brenda L Gallie; Svetlana Saakyan; Anush G Amiryan; Vladimir Valskiy; Kimberly J Chin; Ekaterina Semenova; Stefan Seregard; Maria Filì; Matthew Wilson; Barrett Haik; Josep Maria Caminal; Jaume Catala-Mora; Cristina Gutiérrez; David E Pelayes; Anibal Martin Folgar; Martine Johanna Jager; Mehmet Doğrusöz; Gregorius P M Luyten; Arun D Singh; Shigenobu Suzuki Journal: Br J Ophthalmol Date: 2021-01-15 Impact factor: 4.638