| Literature DB >> 24776669 |
Anh Thu Ngoc Lam1, Jinha Yoon1, Erdene-Ochir Ganbold1, Dheeraj K Singh2, Doseok Kim2, Kwang-Hwi Cho3, Sang Jun Son4, Jaebum Choo5, So Yeong Lee6, Sehun Kim7, Sang-Woo Joo8.
Abstract
We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV-Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic C≡C group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that ∼10(-5) M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the dark-field microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells.Entities:
Keywords: Density functional theory; Erlotinib; Gold nanoparticles; Interfacial structures; Raman spectroscopy
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Year: 2014 PMID： 24776669 DOI： 10.1016/j.jcis.2014.03.032
Source DB: PubMed Journal: J Colloid Interface Sci ISSN： 0021-9797 Impact factor: 8.128