Literature DB >> 2477485

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

T Matsuyama1, A Yamada, J Kay, K M Yamada, S K Akiyama, S F Schlossman, C Morimoto.   

Abstract

In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.

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Year:  1989        PMID： 2477485      PMCID： PMC2189458          DOI： 10.1084/jem.170.4.1133

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  52 in total

Review 1.  New perspectives in cell adhesion: RGD and integrins.

Authors:  E Ruoslahti; M D Pierschbacher
Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

Review 2.  The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.

Authors:  T A Springer; M L Dustin; T K Kishimoto; S D Marlin
Journal:  Annu Rev Immunol       Date:  1987       Impact factor: 28.527

3.  The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

Authors:  Y Takada; J L Strominger; M E Hemler
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

Review 4.  Cell surface receptors for extracellular matrix molecules.

Authors:  C A Buck; A F Horwitz
Journal:  Annu Rev Cell Biol       Date:  1987

5.  The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.

Authors:  M E Hemler; C Huang; L Schwarz
Journal:  J Biol Chem       Date:  1987-03-05       Impact factor: 5.157

6.  Fibronectin receptor structures in the VLA family of heterodimers.

Authors:  Y Takada; C Huang; M E Hemler
Journal:  Nature       Date:  1987 Apr 9-15       Impact factor: 49.962

7.  Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits.

Authors:  M H Ginsberg; J Loftus; J J Ryckwaert; M Pierschbacher; R Pytela; E Ruoslahti; E F Plow
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

8.  The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens.

Authors:  C E Rudd; C Morimoto; L L Wong; S F Schlossman
Journal:  J Exp Med       Date:  1987-12-01       Impact factor: 14.307

9.  Lymphoid precursor cells adhere to two different sites on fibronectin.

Authors:  P Bernardi; V P Patel; H F Lodish
Journal:  J Cell Biol       Date:  1987-07       Impact factor: 10.539

10.  Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.

Authors:  K M Yamada; D W Kennedy
Journal:  J Cell Biol       Date:  1984-07       Impact factor: 10.539
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  77 in total

1.  Cytotoxic T-lymphocyte interaction with fibronectin and vitronectin: activated adhesion and cosignalling.

Authors:  B Ybarrondo; A M O'Rourke; J B McCarthy; M F Mescher
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

2.  Fibronectin-mononuclear cell interactions regulate type 1 helper T cell cytokine network in tolerant transplant recipients.

Authors:  A J Coito; K Onodera; H Kato; R W Busuttil; J W Kupiec-Weglinski
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

3.  Convergence between CD98 and integrin-mediated T-lymphocyte co-stimulation.

Authors:  A P Warren; K Patel; Y Miyamoto; J N Wygant; D G Woodside; B W McIntyre
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

Review 4.  Diverse roles of integrins in human T lymphocyte biology.

Authors:  Yuko J Miyamoto; Bernard F Andruss; Jason S Mitchell; Matthew J Billard; Bradley W McIntyre
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

Review 5.  The role of adhesion molecules in endothelial cell accessory function.

Authors:  J R Westphal; R M de Waal
Journal:  Mol Biol Rep       Date:  1992-11       Impact factor: 2.316

6.  Early T-cell defects in pre-type 1 diabetes.

Authors:  L al Sakkaf; P Pozzilli; P J Bingley; M W Lowdell; J M Thomas; E Bonifacio; E A Gale; G F Bottazzo
Journal:  Acta Diabetol       Date:  1992       Impact factor: 4.280

7.  Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.

Authors:  Qing Li; Xuedong Ding; Jeremy J Thomas; Clifford V Harding; Nicole D Pecora; Assem G Ziady; Samuel Shank; W Henry Boom; Christina L Lancioni; Roxana E Rojas
Journal:  J Leukoc Biol       Date:  2011-12-07       Impact factor: 4.962

8.  B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

Authors:  C D Gimmi; G J Freeman; J G Gribben; K Sugita; A S Freedman; C Morimoto; L M Nadler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

9.  Purification of an Arg-Gly-Asp selective matrix receptor from brain synaptic plasma membranes.

Authors:  B A Bahr; G Lynch
Journal:  Biochem J       Date:  1992-01-01       Impact factor: 3.857

10.  Interaction of the cell-binding domain of fibronectin with VLA-5 integrin induces monokine production in cultured human monocytes.

Authors:  T Takizawa; S Nishinarita; N Kitamura; J Hayakawa; H Kang; Y Tomita; K Mitamura; K Yamagami; T Horie
Journal:  Clin Exp Immunol       Date:  1995-08       Impact factor: 4.330
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