Zhi-chang Zhao1, Xiao-hong Xu2, Mao-bai Liu1, Juan Wu2, Juan Lin2, Bin Li3. 1. Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. 2. Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. 3. Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. Electronic address: leonlee307@hotmail.com.
Abstract
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) is widespread in China. To date, no study available has specifically determined the prevalence and risk factors of inpatients with CRE intestinal colonization in this region. METHODS: Stool samples were screened for the presence of CRE in a Chinese university hospital. A case-control study was performed to identify risk factors associated with CRE fecal colonization. Case patients were those who had CRE colonization. Control subjects had no microbiologic evidence of CRE colonization. Clinical data were obtained from the medical record. RESULTS: The prevalence of CRE was 6.6% (20/303 patients), of which 8 had carbapenemase-producing isolates. KPC-2, IMP-4, and NDM-1 were detected from these isolates. Hospital readmissions (odds ratio [OR], 58.067; 95% confidence interval [95% CI]: 5.517-611.134; P = .001), sickbed changes (OR, 45.904; 95% CI: 8.484-248.376; P < .001), invasive procedures (OR, 8.322; 95% CI: 1.996-34.690; P = .004), and vancomycin (OR, 11.552; 95% CI: 1.155-115.574; P = .037) were independently associated with CRE colonization. CONCLUSION: This study demonstrated that asymptomatic intestinal carriage of CRE was relatively common in one region of China. Our study suggested that the implementation of effective infection control measures is urgently required to control the transmission of CRE in health care facilities in this country.
BACKGROUND:Carbapenem-resistant Enterobacteriaceae (CRE) is widespread in China. To date, no study available has specifically determined the prevalence and risk factors of inpatients with CRE intestinal colonization in this region. METHODS: Stool samples were screened for the presence of CRE in a Chinese university hospital. A case-control study was performed to identify risk factors associated with CRE fecal colonization. Case patients were those who had CRE colonization. Control subjects had no microbiologic evidence of CRE colonization. Clinical data were obtained from the medical record. RESULTS: The prevalence of CRE was 6.6% (20/303 patients), of which 8 had carbapenemase-producing isolates. KPC-2, IMP-4, and NDM-1 were detected from these isolates. Hospital readmissions (odds ratio [OR], 58.067; 95% confidence interval [95% CI]: 5.517-611.134; P = .001), sickbed changes (OR, 45.904; 95% CI: 8.484-248.376; P < .001), invasive procedures (OR, 8.322; 95% CI: 1.996-34.690; P = .004), and vancomycin (OR, 11.552; 95% CI: 1.155-115.574; P = .037) were independently associated with CRE colonization. CONCLUSION: This study demonstrated that asymptomatic intestinal carriage of CRE was relatively common in one region of China. Our study suggested that the implementation of effective infection control measures is urgently required to control the transmission of CRE in health care facilities in this country.
Authors: H Solgi; F Badmasti; Z Aminzadeh; C G Giske; M Pourahmad; F Vaziri; S A Havaei; F Shahcheraghi Journal: Eur J Clin Microbiol Infect Dis Date: 2017-06-21 Impact factor: 3.267
Authors: Pedro Torres-Gonzalez; Miguel Enrique Cervera-Hernandez; María Dolores Niembro-Ortega; Francisco Leal-Vega; Luis Pablo Cruz-Hervert; Lourdes García-García; Arturo Galindo-Fraga; Areli Martinez-Gamboa; Miriam Bobadilla-Del Valle; Jose Sifuentes-Osornio; Alfredo Ponce-de-Leon Journal: PLoS One Date: 2015-10-02 Impact factor: 3.240