| Literature DB >> 2477263 |
D Trerè1, A Pession, M Derenzini.
Abstract
The relationship between interphasic silver-stained proteins of the nucleolar organizer regions (Ag-NOR proteins) and cell replication rate has been studied in 13 established neuroblastoma cell lines. The quantity of Ag-NOR proteins was measured in silver-stained cells by means of an automated image analyzer. The results indicated that the amount of Ag-NOR proteins is strictly proportional to the proliferative activity of the cells. Cell lines with a difference of only 4 h in doubling time were characterized by a statistically significant difference in Ag-NOR protein amount. The Ag-NOR protein quantity can therefore be used as a parameter for evaluating the cell proliferation rate.Entities:
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Year: 1989 PMID： 2477263 DOI： 10.1016/0014-4827(89)90371-6
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905