Literature DB >> 2477140

Accumulation of smooth endoplasmic reticulum in Alzheimer's disease: new morphological evidence of axoplasmic flow disturbances.

S Richard1, J P Brion, A M Couck, J Flament-Durand.   

Abstract

Numerous enlarged neurites and presynaptic terminals containing tubulovesicular profiles of smooth endoplasmic reticulum (SER) were observed in frontal biopsies from six patients with Alzheimer's disease. These accumulations of SER probably reflect disturbances of axoplasmic flows. In addition, curvilinear tubular inclusions similar to those characteristic of Farber's disease were found in one patient. Finally, accumulation of glycogen within neurites and enlarged mitochondria were observed in all patients.

Entities:  

Mesh：

Year:  1989        PMID： 2477140

Source DB:  PubMed          Journal:  J Submicrosc Cytol Pathol        ISSN： 1122-9497


  8 in total

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8.  Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.

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  8 in total

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