Literature DB >> 2477115

Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

G O Ivy1, K Kitani, Y Ihara.   

Abstract

Rats received intraventricular infusion of leupeptin or saline and brain sections were immunostained with antibodies to tau (anti-HFoPHF) or ubiquitin. Results were compared with immunostaining on normal aged rat brains and Alzheimer's disease (AD) brains. Both antibodies stained Purkinje cell perikarya and dendrites of leupeptin (but not saline)-treated and aged rat brains, as well as senile plaque neurites and neurofibrillary tangles in AD brains. The results are consistent with the hypothesis that paired helical filament (PHF) formation involves defective protein degradation.

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Year:  1989        PMID： 2477115     DOI： 10.1016/0006-8993(89)91117-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

Review 1.  The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review.

Authors:  R A Nixon; A M Cataldo; P M Mathews
Journal:  Neurochem Res       Date:  2000-10       Impact factor: 3.996

2.  Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization.

Authors:  B Bacci; E Cochran; M G Nunzi; E Izeki; T Mizutani; A Patton; S Hite; L M Sayre; L Autilio-Gambetti; P Gambetti
Journal:  Am J Pathol       Date:  1994-04       Impact factor: 4.307

3.  Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus.

Authors:  E Bednarski; C E Ribak; G Lynch
Journal:  J Neurosci       Date:  1997-06-01       Impact factor: 6.167

4.  Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation.

Authors:  Fu Shang; Gejing Deng; Qing Liu; Weimin Guo; Arthur L Haas; Bernat Crosas; Daniel Finley; Allen Taylor
Journal:  J Biol Chem       Date:  2005-03-24       Impact factor: 5.157

5.  Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease.

Authors:  E Cochran; B Bacci; Y Chen; A Patton; P Gambetti; L Autilio-Gambetti
Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

6.  Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.

Authors:  S Takauchi; K Miyoshi
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

7.  Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

Authors:  S A Frautschy; D L Horn; J J Sigel; M E Harris-White; J J Mendoza; F Yang; T C Saido; G M Cole
Journal:  J Neurosci       Date:  1998-10-15       Impact factor: 6.167

8.  Amyloid enhancing factor activity is associated with ubiquitin.

Authors:  K Alizadeh-Khiavi; J Normand; S Chronopoulos; A Ali; Z Ali-Khan
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

Review 9.  Lysosomes and brain aging in mammals.

Authors:  Gary Lynch; Xiaoning Bi
Journal:  Neurochem Res       Date:  2003-11       Impact factor: 3.996
  9 in total

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