S B Paparo1, M A Guaragna1, M Albanesi2. 1. Department of Clinical and Molecular Medicine, Faculty of Medicine and Psycology, "Sapienza" University of Rom, Italy. 2. Department of Immunology, Institute Pasteur, Paris, France.
Abstract
OBJECTIVE: The concomitance of psoriasis and high IgE levels in the same patient, possibly associated to allergies, should not come as a surprise anymore, because both diseases are characterised by an immunological disorder, involving cytokines and other inflammatory mediators, with massive activation of the cell-mediated immunity. MATERIALS AND METHODS: During a period of 18 months, using a radio-immunologic method, we assessed the level of IgE in patients with severe psoriasis who were not responding to the common therapy. RESULTS: Patients with severe psoriasis had high levels of IgE. CONCLUSIONS: IgEs have an important role in pathogenesis of psoriasis and atopic dermatitis, but the mechanism is not yet clear.
OBJECTIVE: The concomitance of psoriasis and high IgE levels in the same patient, possibly associated to allergies, should not come as a surprise anymore, because both diseases are characterised by an immunological disorder, involving cytokines and other inflammatory mediators, with massive activation of the cell-mediated immunity. MATERIALS AND METHODS: During a period of 18 months, using a radio-immunologic method, we assessed the level of IgE in patients with severe psoriasis who were not responding to the common therapy. RESULTS:Patients with severe psoriasis had high levels of IgE. CONCLUSIONS: IgEs have an important role in pathogenesis of psoriasis and atopic dermatitis, but the mechanism is not yet clear.