OBJECTIVE: to evaluate the role of fibrillar extracellular matrix components in the pathogenesis of inguinal hernias. METHODS: samples of the transverse fascia and of the anterior sheath of the rectus abdominis muscle were collected from 40 men aged between 20 and 60 years with type II and IIIA Nyhus inguinal hernia and from 10 fresh male cadavers (controls) without hernia in the same age range. The staining technique was immunohistochemistry for collagen I, collagen III and elastic fibers; quantification of fibrillar components was performed with an image analysis processing software. RESULTS: no statistically significant differences were found in the amount of elastic fibers, collagen I and collagen III, and the ratio of collagen I / III among patients with inguinal hernia when compared with subjects without hernia. CONCLUSION: the amount of fibrillar extracellular matrix components did not change in patients with and without inguinal hernia.
OBJECTIVE: to evaluate the role of fibrillar extracellular matrix components in the pathogenesis of inguinal hernias. METHODS: samples of the transverse fascia and of the anterior sheath of the rectus abdominis muscle were collected from 40 men aged between 20 and 60 years with type II and IIIA Nyhus inguinal hernia and from 10 fresh male cadavers (controls) without hernia in the same age range. The staining technique was immunohistochemistry for collagen I, collagen III and elastic fibers; quantification of fibrillar components was performed with an image analysis processing software. RESULTS: no statistically significant differences were found in the amount of elastic fibers, collagen I and collagen III, and the ratio of collagen I / III among patients with inguinal hernia when compared with subjects without hernia. CONCLUSION: the amount of fibrillar extracellular matrix components did not change in patients with and without inguinal hernia.
Authors: João Vicente Machado Grossi; Felipe Fernandes Nicola; Ivan Alberto Zepeda; Martina Becker; Eduardo Neubarth Trindade; Vinicius Von Diemen; Leandro Totti Cavazzola; Manoel Roberto Maciel Trindade Journal: Arq Bras Cir Dig Date: 2016
Authors: Suluh Darmadi; Joko Hendarto; Ibrahim Labeda; Ronald Erasio Lusikooy; Samuel Sampetoding; Muhammad Iwan Dani; Muhammad Ihwan Kusuma; Julianus Aboyaman Uwuratuw; Erwin Syarifuddin; Muhammad Faruk Journal: Ann Med Surg (Lond) Date: 2021-07-16