Literature DB >> 2477065

The contribution of ATP turnover by the Na+/K+-ATPase to the rate of respiration of hepatocytes. Effects of thyroid status and fatty acids.

C D Nobes1, P L Lakin-Thomas, M D Brand.   

Abstract

In less than 1 min ouabain maximally inhibits oxygen consumption due to gramicidin-induced ATP turnover by the Na+/K+-ATPase in hepatocytes. Ouabain rapidly inhibits respiration on palmitate or glucose by only 6-10% indicating that the Na+/K+-ATPase plays a minor role in cell ATP turnover. 29% of the extra oxygen consumption of hepatocytes isolated from hyperthyroid rats was inhibited by ouabain showing that the Na+/K+-ATPase is responsible for some but not the majority of the stimulation of respiration induced by thyroid hormone.

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Year:  1989        PMID： 2477065     DOI： 10.1016/s0005-2728(89)80236-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


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