Literature DB >> 2476997

A search for calcium-channel activators in the verapamil series.

M N Romanelli1, F Gualtieri, R Mannhold, A Chiarini.   

Abstract

A new series of phenylalkylamines related to Verapamil have been synthesized and their Ca2+-modulating activity on rabbit aorta and on guinea-pig heart were evaluated. The compounds display only a moderate Ca2+-antagonistic activity; none of them showed any Ca2+-agonistic effect.

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Year:  1989        PMID： 2476997     DOI： 10.1002/chin.198952109

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  2 in total

1.  Semi-rigid analogues of the calcium antagonist verapamil: a molecular modelling study.

Authors:  M N Romanelli; S Dei; S Scapecchi; E Teodori; F Gualtieri; R Budriesi; R Mannhold
Journal:  J Comput Aided Mol Des       Date:  1994-04       Impact factor: 3.686

2.  Enantioselective synthesis and pharmacological evaluation of a new type of verapamil analog with hypotensive and calcium antagonist activities.

Authors:  H L Holland; J X Gu; F Orallo; M Camiña; P Fabeiro; A J Willetts
Journal:  Pharm Res       Date:  1999-02       Impact factor: 4.200
  2 in total

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