Literature DB >> 2476924

Pharmacological investigation of acute cellular accumulation in immunological air pouch inflammation.

P Hambleton1, P Miller.   

Abstract

Immunologically-mediated cellular accumulation was measured 24 hours after antigenic challenge using a rat subcutaneous air pouch model. This response was inhibited by treatment with prednisolone, colchicine, anti-thymocyte serum and systemic antigen. In contrast, administration of a range of other pharmacological and clinically active agents had little effect. The profile of inhibitory activity suggested that this response was mainly due to delayed type hypersensitivity with little anaphylactic or Arthus-type component.

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Year:  1989        PMID： 2476924     DOI： 10.1007/bf02022983

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  29 in total

1.  Pertussis vaccine pleurisy: a model of delayed hypersensitivity.

Authors:  P A Dieppe; D A Willoughby; E C Huskisson; E Arrigoni-Martelli
Journal:  Agents Actions       Date:  1976-09

2.  Multiple control of inflammation by glucocorticoids.

Authors:  M Di Rosa; A Calignano; R Carnuccio; A Ialenti; L Sautebin
Journal:  Agents Actions       Date:  1986-01

3.  Complement in acute inflammation.

Authors:  D A Willoughby; E Coote; J L Turk
Journal:  J Pathol       Date:  1969-02       Impact factor: 7.996

4.  A model of Arthus pleurisy: modulation by various pharmacologic and therapeutic agents.

Authors:  R J Smith; S S Iden; N A Rohloff
Journal:  Clin Immunol Immunopathol       Date:  1983-01

5.  Immune inflammation in newly developing facsimile synovia.

Authors:  Y M Sin; A D Sedgwick; D A Willoughby
Journal:  Int Arch Allergy Appl Immunol       Date:  1984

6.  Role of polymorphonuclear leukocytes in connective tissue breakdown during the reverse passive Arthus reaction.

Authors:  D S Fletcher; D Osinga; R J Bonney
Journal:  Biochem Pharmacol       Date:  1986-08-01       Impact factor: 5.858

7.  The effects of cyclosporin A on leucocyte infiltration and procoagulant activity in the mouse delayed hypersensitivity response in vivo.

Authors:  C J Dunn; S K Miller
Journal:  Int J Immunopharmacol       Date:  1986

8.  Arachidonate metabolites in acute and chronic allergic air pouch inflammation in rats and the anti-inflammatory effects of indomethacin and dexamethasone.

Authors:  K Ohuchi; M Watanabe; L Levine
Journal:  Int Arch Allergy Appl Immunol       Date:  1984

9.  Modulation of lymphocyte activating factor activity (interleukin 1 like activity) and acute phase proteins in pertussis-induced air pouch inflammation by muramyl dipeptide.

Authors:  A D Sedgwick; R E Hooke; P Lees; S A May
Journal:  Agents Actions       Date:  1987-06

10.  Macrophage activation in rat models of inflammation and arthritis. Systemic activation precedes arthritis induction and progression.

Authors:  W J Johnson; K A Muirhead; P C Meunier; B J Votta; T C Schmitt; M J DiMartino; N Hanna
Journal:  Arthritis Rheum       Date:  1986-09
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  1 in total

Review 1.  Update on colchicine and its mechanism of action.

Authors:  Yair Molad
Journal:  Curr Rheumatol Rep       Date:  2002-06       Impact factor: 4.592
  1 in total

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