Literature DB >> 2476923

Effects of protamine on histamine release from human lung.

J H Levy1, B A Faraj, J R Zaidan, V M Camp.   

Abstract

Animal mast cell models demonstrate direct histamine release by protamine. Investigators have proposed that protamine also releases histamine in man. We studied the effects of protamine alone and heparin-protamine mixtures on minced lung tissue for evidence of histamine release. We were unable to demonstrate the release of histamine despite positive anti-IgE controls. Nonimmunologic histamine release from human lung appears unlikely as a mechanism for protamine reactions in man.

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Year:  1989        PMID： 2476923     DOI： 10.1007/bf02022982

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  12 in total

1.  Comparison of histamine release in human skin mast cells induced by morphine, fentanyl, and oxymorphone.

Authors:  J M Hermens; J M Ebertz; J M Hanifin; C A Hirshman
Journal:  Anesthesiology       Date:  1985-02       Impact factor: 7.892

2.  Inflammatory mediators and mechanisms of release from purified human basophils and mast cells.

Authors:  R P Schleimer; D W MacGlashan; S P Peters; R Naclerio; D Proud; N F Adkinson; L M Lichtenstein
Journal:  J Allergy Clin Immunol       Date:  1984-10       Impact factor: 10.793

3.  Dispersed human lung mast cells. Pharmacologic aspects and comparison with human lung tissue fragments.

Authors:  S P Peters; E S Schulman; R P Schleimer; D W MacGlashan; H H Newball; L M Lichtenstein
Journal:  Am Rev Respir Dis       Date:  1982-12

4.  Protamine-induced circulatory changes.

Authors:  R W Frater; Y Oka; Y Hong; T Tsubo; P G Loubser; R Masone
Journal:  J Thorac Cardiovasc Surg       Date:  1984-05       Impact factor: 5.209

5.  Histamine release from rat mast cells induced by protamine sulfate and polyethylene imine.

Authors:  S Schnitzler; H Renner; U Pfüller
Journal:  Agents Actions       Date:  1981-04

6.  Evaluation of patients at risk for protamine reactions.

Authors:  J H Levy; I M Schwieger; J R Zaidan; B A Faraj; W S Weintraub
Journal:  J Thorac Cardiovasc Surg       Date:  1989-08       Impact factor: 5.209

7.  C5a and thromboxane generation associated with pulmonary vaso- and broncho-constriction during protamine reversal of heparin.

Authors:  D R Morel; W M Zapol; S J Thomas; E M Kitain; D R Robinson; J Moss; D E Chenoweth; E Lowenstein
Journal:  Anesthesiology       Date:  1987-05       Impact factor: 7.892

Review 8.  Protamine: a review of its toxicity.

Authors:  J C Horrow
Journal:  Anesth Analg       Date:  1985-03       Impact factor: 5.108

9.  Cardiovascular effects of protamine sulfate are dependent on the presence and type of circulating heparin.

Authors:  W P Fiser; J E Fewell; D E Hill; R W Barnes; R C Read
Journal:  J Thorac Cardiovasc Surg       Date:  1985-01       Impact factor: 5.209

10.  Development of a sensitive radioassay of histamine for in vitro allergy testing.

Authors:  B A Faraj; G R Gottlieb; V M Camp; M Kutner; P Lolies
Journal:  J Nucl Med       Date:  1984-01       Impact factor: 10.057
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