Literature DB >> 24769067

Production of bone marrow, liver, thymus (BLT) humanized mice on the C57BL/6 Rag2(-/-)γc(-/-)CD47(-/-) background.

Kerry J Lavender1, Ronald J Messer1, Brent Race1, Kim J Hasenkrug2.   

Abstract

C57BL/6 Rag2(-/-)γc(-/-)CD47(-/-) triple-knockout mice engrafted with fetal human bone marrow, liver, thymus (TKO-BLT) not only develop high levels of multi-lineage hematopoiesis but also organized lymphoid tissues including mesenteric lymph nodes, splenic follicles and gut-associated lymphoid tissues of human origin. A unique advantage of these mice is that they sustain human cell and tissue engraftment long-term without the development of graft versus host disease. Thus they can be used for long-term studies not previously feasible with other models. The production of TKO-BLT mice to obtain healthy mice with high level reconstitution of human cells and tissues requires specialized methods that are presented in detail. Published by Elsevier B.V.

Entities:  

Keywords:  BLT humanized mice; C57BL/6 Rag2(−/−)γ(c)(−/−)CD47(−/−); Hematopoiesis

Mesh：

Substances：

Year:  2014        PMID： 24769067      PMCID： PMC4060441          DOI： 10.1016/j.jim.2014.04.008

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  14 in total

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Journal:  Blood       Date:  2006-01-12       Impact factor: 22.113

4.  Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

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