Wieke Haakma1, Pieter Dik2, Bennie ten Haken3, Martijn Froeling4, Rutger A J Nievelstein4, Inge Cuppen5, Tom P V M de Jong6, Alexander Leemans7. 1. Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Forensic Medicine and Comparative Medicine Laboratory, Aarhus University, Aarhus, Denmark. 2. Department of Pediatric Urology, University Children's Hospitals University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: p.dik@umcutrecht.nl. 3. Neuro Imaging, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands. 4. Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. 5. Department of Pediatric Neurology, University Children's Hospitals University Medical Center Utrecht, Utrecht, The Netherlands. 6. Department of Pediatric Urology, University Children's Hospitals University Medical Center Utrecht, Utrecht, The Netherlands. 7. Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Abstract
PURPOSE: It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography. MATERIALS AND METHODS: Ten patients 8 to 16 years old with spina bifida underwent diffusion tensor imaging on a 3 Tesla magnetic resonance imaging system. Anatomical 3-dimensional reconstructions were obtained of the sacral plexus of the 10 patients. Fiber tractography was performed with a diffusion magnetic resonance imaging toolbox to determine fractional anisotropy, and mean, axial and radial diffusivity in the sacral plexus of the patients. Results were compared to 10 healthy controls. RESULTS: Nerves of patients with spina bifida showed asymmetry and disorganization to a large extent compared to those of healthy controls. Especially at the myelomeningocele level it was difficult to find a connection with the cauda equina. Mean, axial and radial diffusivity values at S1-S3 were significantly lower in patients. CONCLUSIONS: To our knowledge this 3 Tesla magnetic resonance imaging study showed for the first time sacral plexus asymmetry and disorganization in 10 patients with spina bifida using diffusion tensor imaging and fiber tractography. The observed difference in diffusion values indicates that these methods may be used to identify nerve abnormalities. We expect that this technique could provide a valuable contribution to better analysis and understanding of the problems of patients with spina bifida in the future.
PURPOSE: It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography. MATERIALS AND METHODS: Ten patients 8 to 16 years old with spina bifida underwent diffusion tensor imaging on a 3 Tesla magnetic resonance imaging system. Anatomical 3-dimensional reconstructions were obtained of the sacral plexus of the 10 patients. Fiber tractography was performed with a diffusion magnetic resonance imaging toolbox to determine fractional anisotropy, and mean, axial and radial diffusivity in the sacral plexus of the patients. Results were compared to 10 healthy controls. RESULTS: Nerves of patients with spina bifida showed asymmetry and disorganization to a large extent compared to those of healthy controls. Especially at the myelomeningocele level it was difficult to find a connection with the cauda equina. Mean, axial and radial diffusivity values at S1-S3 were significantly lower in patients. CONCLUSIONS: To our knowledge this 3 Tesla magnetic resonance imaging study showed for the first time sacral plexus asymmetry and disorganization in 10 patients with spina bifida using diffusion tensor imaging and fiber tractography. The observed difference in diffusion values indicates that these methods may be used to identify nerve abnormalities. We expect that this technique could provide a valuable contribution to better analysis and understanding of the problems of patients with spina bifida in the future.
Authors: Nathan Maassel; James Farrelly; Daniel Coman; Mollie Freedman-Weiss; Samantha Ahle; Sarah Ullrich; Nicholas Yung; Fahmeed Hyder; David Stitelman Journal: PLoS One Date: 2021-06-30 Impact factor: 3.240
Authors: Wieke Haakma; Bas A Jongbloed; Martijn Froeling; H Stephan Goedee; Clemens Bos; Alexander Leemans; Leonard H van den Berg; Jeroen Hendrikse; W Ludo van der Pol Journal: Eur Radiol Date: 2016-09-21 Impact factor: 5.315