| Literature DB >> 2476882 |
M A Ferro1, D Gillatt, M O Symes, P J Smith.
Abstract
High-dose intravenous estrogen therapy was shown to be effective in relieving bone pain due to metastatic disease in 22 of 29 (75.9%) men with advanced hormone-resistant prostate cancer. This clinical response was accompanied by significant falls in serum prostate-specific antigen (PSA) levels in 13 (44.8%) patients. It is suggested that this clinical benefit is due to a direct inhibitory effect of estrogen on prostate cancer cells.Entities:
Mesh:
Substances:
Year: 1989 PMID: 2476882 DOI: 10.1016/0090-4295(89)90248-3
Source DB: PubMed Journal: Urology ISSN: 0090-4295 Impact factor: 2.649