Mieke Boon1, Kris De Boeck2, Mark Jorissen3, Isabelle Meyts4. 1. Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Electronic address: mieke.boon@uzleuven.be. 2. Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. 3. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, Belgium. 4. Department of Pediatrics, Pediatric Immunology, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium.
Abstract
BACKGROUND: Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections. OBJECTIVE: To examine the concurrence of PCD and HID in a patient cohort with known PCD. METHODS: Retrospective review of the patient files. RESULTS: We describe 11 patients of a cohort of 168 patients with PCD (6.5%) with a combination of PCD and some form of HID. The patients all presented with typical clinical symptoms for PCD, however the role of the concomitant immunological abnormalities is not clear. CONCLUSION: PCD and HID coincided in 6.5% of the patients. We suggest that a common pathophysiological pathway results in both disorders.
BACKGROUND:Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections. OBJECTIVE: To examine the concurrence of PCD and HID in a patient cohort with known PCD. METHODS: Retrospective review of the patient files. RESULTS: We describe 11 patients of a cohort of 168 patients with PCD (6.5%) with a combination of PCD and some form of HID. The patients all presented with typical clinical symptoms for PCD, however the role of the concomitant immunological abnormalities is not clear. CONCLUSION:PCD and HID coincided in 6.5% of the patients. We suggest that a common pathophysiological pathway results in both disorders.
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