Literature DB >> 2476851

Sequence-specific isotope effects on the cleavage of DNA by bleomycin.

J W Kozarich1, L Worth, B L Frank, D F Christner, D E Vanderwall, J Stubbe.   

Abstract

Bleomycin is a metal- and oxygen-dependent DNA cleaver. The chemistry of DNA damage has been proposed to involve rate-limiting abstraction of the 4'-hydrogen. A DNA fragment has been prepared that contains [4'-2H]thymidine residues of high isotopic content. Primary kinetic isotope effects have been directly observed at individual thymidine residues with DNA sequencing technology.

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Year:  1989        PMID： 2476851     DOI： 10.1126/science.2476851

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  19 in total

1.  Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator.

Authors:  Valérie C Pierre; Jens T Kaiser; Jacqueline K Barton
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-28       Impact factor: 11.205

2.  Reactivity of Nucleic Acid Radicals.

Authors:  Marc M Greenberg
Journal:  Adv Phys Org Chem       Date:  2016       Impact factor: 2.833

3.  New Chemical and Stereochemical Applications of Organoiron Complexes.

Authors:  Alexander J Fatiadi
Journal:  J Res Natl Inst Stand Technol       Date:  1991 Jan-Feb

4.  Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers.

Authors:  M Bansal; J S Lee; J Stubbe; J W Kozarich
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

5.  Characterization of bleomycin-mediated cleavage of a hairpin DNA library.

Authors:  Zachary J Segerman; Basab Roy; Sidney M Hecht
Journal:  Biochemistry       Date:  2013-07-22       Impact factor: 3.162

6.  DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone.

Authors:  B Balasubramanian; W K Pogozelski; T D Tullius
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

7.  Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA.

Authors:  Trevor C Bozeman; Rupesh Nanjunda; Chenhong Tang; Yang Liu; Zachary J Segerman; Paul A Zaleski; W David Wilson; Sidney M Hecht
Journal:  J Am Chem Soc       Date:  2012-10-22       Impact factor: 15.419

8.  Bleomycin mediated degradation of DNA-RNA hybrids does not involve C-1' chemistry.

Authors:  M J Absalon; C R Krishnamoorthy; G McGall; J W Kozarich; J Stubbe
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

9.  Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

Authors:  N Zein; K L Colson; J E Leet; D R Schroeder; W Solomon; T W Doyle; A M Casazza
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

10.  GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin.

Authors:  Bingzi Chen; Xinfeng Zhou; Koli Taghizadeh; Jingyang Chen; JoAnne Stubbe; Peter C Dedon
Journal:  Chem Res Toxicol       Date:  2007-10-19       Impact factor: 3.739
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