Amir A Mahabadi1, Marie H Geisel2, Nils Lehmann2, Christian Lammerding3, Hagen Kälsch3, Marcus Bauer3, Susanne Moebus2, Karl-Heinz Jöckel2, Raimund Erbel3, Stefan Möhlenkamp4. 1. West German Heart Center, Department of Cardiology, University of Duisburg-Essen, Essen, Germany. Electronic address: amir-abbas.mahabadi@uk-essen.de. 2. Institute of Medical Informatics, Biometry, and Epidemiology, University of Duisburg-Essen, Essen, Germany. 3. West German Heart Center, Department of Cardiology, University of Duisburg-Essen, Essen, Germany. 4. West German Heart Center, Department of Cardiology, University of Duisburg-Essen, Essen, Germany; Krankenhaus Bethanien, Department of Cardiology, Moers, Germany.
Abstract
BACKGROUND: Echocardiography based data suggests that left atrial (LA) size is associated with cardiovascular morbidity and mortality. Once non-contrast cardiac CT is performed for prevention purposes, information on the LA is readily available. We aimed to determine whether LA area from non-contrast cardiac CT is associated with incident major cardiovascular (CV) events, independent of CV risk factors and coronary artery calcium (CAC), based on a general population cohort. METHODS: Subjects aged 45-75 years without prevalent CV disease from the population-based Heinz Nixdorf Recall Study were enrolled between 2000 and 2003. LA area at the level of the mitral valve was quantified from non-contrast cardiac CT. Major CV events (coronary event, stroke, CV death) were assessed during follow-up. The association of LA with events was assessed using Cox regression analysis. RESULTS: Overall, 3958 subjects (59.2 ± 7.7 years, 53% female) were included. Mean LA area was 17.64 ± 4.22 cm(2) (range: 7.16-44.13 cm(2)). During 8.0 ± 1.5 years of follow-up, 221 major CV events occurred. In univariate analysis, increase of LA size by 1 standard deviation was associated with nearly 50% excess events (HR (95%CI): 1.48 (1.32-1.65)), which remained significant after adjustment for CV risk factors (HR (95%CI): 1.25 (1.09-1.43)) and when additionally adjusting for CAC (HR (95%CI): 1.22 (1.07-1.40)). Associations for LA size were similar for each endpoint and again independent of risk factors and CAC (coronary event: HR (95%CI): 1.21 (1.01-1.45); stroke: 1.31 (1.05-1.63); CV death: 1.33 (1.03-1.71)). CONCLUSION: LA size is associated with incident major CV events independent of risk factors and CAC-score. Once cardiac CT imaging is performed, assessment of LA size may complement information of this imaging modality.
BACKGROUND: Echocardiography based data suggests that left atrial (LA) size is associated with cardiovascular morbidity and mortality. Once non-contrast cardiac CT is performed for prevention purposes, information on the LA is readily available. We aimed to determine whether LA area from non-contrast cardiac CT is associated with incident major cardiovascular (CV) events, independent of CV risk factors and coronary artery calcium (CAC), based on a general population cohort. METHODS: Subjects aged 45-75 years without prevalent CV disease from the population-based Heinz Nixdorf Recall Study were enrolled between 2000 and 2003. LA area at the level of the mitral valve was quantified from non-contrast cardiac CT. Major CV events (coronary event, stroke, CV death) were assessed during follow-up. The association of LA with events was assessed using Cox regression analysis. RESULTS: Overall, 3958 subjects (59.2 ± 7.7 years, 53% female) were included. Mean LA area was 17.64 ± 4.22 cm(2) (range: 7.16-44.13 cm(2)). During 8.0 ± 1.5 years of follow-up, 221 major CV events occurred. In univariate analysis, increase of LA size by 1 standard deviation was associated with nearly 50% excess events (HR (95%CI): 1.48 (1.32-1.65)), which remained significant after adjustment for CV risk factors (HR (95%CI): 1.25 (1.09-1.43)) and when additionally adjusting for CAC (HR (95%CI): 1.22 (1.07-1.40)). Associations for LA size were similar for each endpoint and again independent of risk factors and CAC (coronary event: HR (95%CI): 1.21 (1.01-1.45); stroke: 1.31 (1.05-1.63); CV death: 1.33 (1.03-1.71)). CONCLUSION: LA size is associated with incident major CV events independent of risk factors and CAC-score. Once cardiac CT imaging is performed, assessment of LA size may complement information of this imaging modality.
Authors: Wael A AlJaroudi; Andrew J Einstein; Farooq A Chaudhry; Steven G Lloyd; Fadi G Hage Journal: J Nucl Cardiol Date: 2015-02-20 Impact factor: 5.952
Authors: Petr Kuchynka; Jana Podzimkova; Martin Masek; Lukas Lambert; Vladimir Cerny; Barbara Danek; Tomas Palecek Journal: Biomed Res Int Date: 2015-07-07 Impact factor: 3.411