| Literature DB >> 2476835 |
M Opp1, F Obal, A B Cady, L Johannsen, J M Krueger.
Abstract
Interleukin-6 (IL6) induces acute phase protein production and is hypothesized to mediate systemic and central effects of IL1. To determine whether IL6 possesses somnogenic properties, rabbits were injected intracerebroventricularly with IL6; sleep-wake activity was determined and brain temperatures recorded for 6 hr. IL6 induced fever in a dose-related manner with no effect on sleep-wake activity. IL6, therefore, is the first cytokine reported to elicit fever without promoting sleep. We conclude that the somnogenic action of IL1 is not mediated through IL6.Entities:
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Year: 1989 PMID： 2476835 DOI： 10.1016/0031-9384(89)90239-4
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384