Literature DB >> 24767823

Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase.

A Jadoon1, P Cunningham2, L C McDermott3.   

Abstract

Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition. We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition. Crown
Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Arachidonic acid; Leukotrienes; Lipoxygenase; Metabolism; Protein–protein interactions

Mesh：

Substances：

Year:  2014        PMID： 24767823     DOI： 10.1016/j.placenta.2014.03.024

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  6 in total

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  6 in total

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