Ye Song1, Yuan Li, Wen Lu, Yuan Gao2. 1. Department of Ultrasound, Affiliated Tongji Hospital, Tongji University, Shanghai 200065, China. 2. Email:gao_yuan68@hotmail.com.
Abstract
OBJECTIVE: To explore the value of contrast-enhanced ultrasound (CEUS) as a new method in evaluating the correlation between muscle perfusion deficits and collateralization in lower extremity arterial disease (LEAD). METHODS: Ultrasound contrast agent was injected into peripheral vein of 80 control subjects and 80 LEAD patients. Its appearance in calf muscle was detected by contrast-enhanced ultrasound. Time intensity curves (TIC) and time to peak intensity (TTP) were analyzed. And collateral formation was evaluated by computed tomography angiography (CTA) . RESULTS: TTP in LEAD group was statistically higher than that in control group (59.1 vs 38.6 s, P < 0.01) . The TTP difference between two investigators who evaluate the row data in a blinded way was 0.29 s and the area under receiver operating characteristic (ROC) curve 0.92. A TTP cutoff at 47.5 s was associated with 91% positive predictive value statistically. TTP in LEAD with bad collateralization was statistically higher than that in LEAD with good collateralization (67.9 vs 50.4 s, P < 0.01) . CONCLUSION: As a consistent method of evaluating muscle perfusion deficits, CEUS shows a good correlation with the extent of collateral formation in LEAD.
OBJECTIVE: To explore the value of contrast-enhanced ultrasound (CEUS) as a new method in evaluating the correlation between muscle perfusion deficits and collateralization in lower extremity arterial disease (LEAD). METHODS: Ultrasound contrast agent was injected into peripheral vein of 80 control subjects and 80 LEAD patients. Its appearance in calf muscle was detected by contrast-enhanced ultrasound. Time intensity curves (TIC) and time to peak intensity (TTP) were analyzed. And collateral formation was evaluated by computed tomography angiography (CTA) . RESULTS: TTP in LEAD group was statistically higher than that in control group (59.1 vs 38.6 s, P < 0.01) . The TTP difference between two investigators who evaluate the row data in a blinded way was 0.29 s and the area under receiver operating characteristic (ROC) curve 0.92. A TTP cutoff at 47.5 s was associated with 91% positive predictive value statistically. TTP in LEAD with bad collateralization was statistically higher than that in LEAD with good collateralization (67.9 vs 50.4 s, P < 0.01) . CONCLUSION: As a consistent method of evaluating muscle perfusion deficits, CEUS shows a good correlation with the extent of collateral formation in LEAD.