| Literature DB >> 24767254 |
Saori Omori1, Katsuhiro Mabe2, Kanako Hatanaka3, Masayoshi Ono1, Mio Matsumoto1, Masakazu Takahashi1, Takeshi Yoshida4, Shoko Ono5, Yuichi Shimizu4, Nozomi Sugai6, Akira Suzuki7, Shinichi Katsuki8, Takahiro Fujii9, Mototsugu Kato5, Masahiro Asaka10, Naoya Sakamoto4.
Abstract
It remains unclear whether or not human intestinal spirochetosis (HIS) has any associated symptoms or lesions. In this study, we assessed the prevalence of HIS in sessile serrated adenomas/polyps (SSA/Ps) and their possible association. Following identification of early cecal cancer with SSA/P accompanied by a colonization of HIS, we went on to conduct a retrospective case-control study using endoscopically resected SSA/P specimens to examine the frequency of HIS infection in SSA/Ps. Nineteen SSA/P cases and 172 controls were obtained. The rate of HIS infection was significantly higher at 52.6% (10/19) in the SSA/P cases compared to the controls at 8.1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps.Entities:
Keywords: Human intestinal spirochetosis; Serrated lesion; Sessile serrated adenoma/polyps
Mesh：
Year: 2014 PMID： 24767254 DOI： 10.1016/j.prp.2014.03.007
Source DB: PubMed Journal: Pathol Res Pract ISSN： 0344-0338 Impact factor: 3.250