Literature DB >> 24766884

Meet the terminator: The phosphatase PP2A puts brakes on IRF-3 activation.

Saurabh Chattopadhyay1, Ganes C Sen2.   

Abstract

Cellular interferon response to microbial infection is transient. In a recent paper in Immunity, Long et al. (2014) identify protein phosphatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription factor for interferon synthesis, thus providing one basis for the observed transiency.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24766884      PMCID： PMC4053166          DOI： 10.1016/j.molcel.2014.04.008

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  8 in total

Review 1.  The IRF family transcription factors at the interface of innate and adaptive immune responses.

Authors:  Hiroaki Ikushima; Hideo Negishi; Tadatsugu Taniguchi
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2013-10-03

Review 2.  Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

Authors:  Taro Kawai; Shizuo Akira
Journal:  Immunity       Date:  2011-05-27       Impact factor: 31.745

3.  Viral apoptosis is induced by IRF-3-mediated activation of Bax.

Authors:  Saurabh Chattopadhyay; Joao T Marques; Michifumi Yamashita; Kristi L Peters; Kevin Smith; Avanti Desai; Bryan R G Williams; Ganes C Sen
Journal:  EMBO J       Date:  2010-04-01       Impact factor: 11.598

Review 4.  Immunomodulatory functions of type I interferons.

Authors:  José M González-Navajas; Jongdae Lee; Michael David; Eyal Raz
Journal:  Nat Rev Immunol       Date:  2012-01-06       Impact factor: 53.106

5.  The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.

Authors:  Michael A Reid; Wen-I Wang; Kimberly Romero Rosales; Meng Xu Welliver; Min Pan; Mei Kong
Journal:  Mol Cell       Date:  2013-03-14       Impact factor: 17.970

Review 6.  Serine/threonine phosphatases: mechanism through structure.

Authors:  Yigong Shi
Journal:  Cell       Date:  2009-10-30       Impact factor: 41.582

Review 7.  Triggering the innate antiviral response through IRF-3 activation.

Authors:  John Hiscott
Journal:  J Biol Chem       Date:  2007-03-29       Impact factor: 5.157

8.  Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.

Authors:  Saurabh Chattopadhyay; Volker Fensterl; Ying Zhang; Manoj Veleeparambil; Jaime L Wetzel; Ganes C Sen
Journal:  MBio       Date:  2013-03-26       Impact factor: 7.867
  8 in total
  1 in total

1.  PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production.

Authors:  Jiayu Xu; Lu Zhang; Yunfei Xu; He Zhang; Junxin Gao; Qian Wang; Zhijun Tian; Lv Xuan; Hongyan Chen; Yue Wang
Journal:  Viruses       Date:  2019-10-15       Impact factor: 5.048
  1 in total

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