| Literature DB >> 24766800 |
Nick R Leslie1, Jeroen den Hertog2.
Abstract
Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.Entities:
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Year: 2014 PMID： 24766800 DOI： 10.1016/j.cell.2014.04.008
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582