Literature DB >> 24766303

PLCE1 suppresses p53 expression in esophageal cancer cells.

Yun Li1, Jun An, Shaohong Huang, Hongying Liao, Yimin Weng, Songwang Cai, Junhang Zhang.   

Abstract

The apoptotic mechanism dysfunction plays a critical role in cancer cell growth and escaping from cancer therapies; the underlying mechanisms are to be further elucidated. This study aims to investigate the role of phospholipase C epsilon 1 (PLCE1) in modulating the apoptosis mechanism in esophageal cancer (Eca) cells. The results showed that Eca cell lines, OE33 and CP-C cells expressed high levels of PLCE1. Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation.

Entities:  

Keywords:  Apoptosis; Esophageal cancer; P53; Phospholipase C epsilon 1; Signal transducer and activator of transcription 3

Mesh：

Substances：

Year:  2014        PMID： 24766303     DOI： 10.3109/07357907.2014.905588

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  15 in total

1.  Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma.

Authors:  Xiaobin Cui; Kaige Wang; Xinqian Yang; Hao Peng; Xi Chen; Huahua Xin; Yanxia Tian; Yunzhao Chen; Feng Li
Journal:  Mol Cell Biochem       Date:  2017-12-13       Impact factor: 3.396

2.  Genome-wide association study identified PLCE1- rs2797992 and EGFR- rs6950826 were associated with TP53 expression in the HBV-related hepatocellular carcinoma of Chinese patients in Guangxi.

Authors:  Xiwen Liao; Chuangye Han; Wei Qin; Xiaoguang Liu; Long Yu; Sicong Lu; Zhiwei Chen; Guangzhi Zhu; Hao Su; Zengnan Mo; Xue Qin; Tao Peng
Journal:  Am J Transl Res       Date:  2016-04-15       Impact factor: 4.060

3.  Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.

Authors:  Zhenzong Du; Kui Ma; Xiaolin Sun; Angui Li; Haiyong Wang; Lifei Zhang; Feng Lin; Xiaoyan Feng; Jianfei Song
Journal:  World J Surg Oncol       Date:  2015-04-08       Impact factor: 2.754

4.  Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.

Authors:  Xiao-Bin Cui; Su Li; Ting-Ting Li; Hao Peng; Ting-Ting Jin; Shu-Mao Zhang; Chun-Xia Liu; Lan Yang; Yao-Yuan Shen; Shu-Gang Li; Na Li; Yong Li; Jian-Ming Hu; Jin-Fang Jiang; Jing Suo; Yan Qi; Wei-Hua Liang; Liang-Hai Wang; Hong-Wei Dang; Li Li; Wei-Wei Cao; Yutao Wei; Chuan-Yue Wu; Xiang-Lin Yuan; Hong Zhou; Yu Zheng; Yun-Zhao Chen; Feng Li
Journal:  Oncotarget       Date:  2016-01-12

5.  Low PLCE1 levels are correlated with poor prognosis in hepatocellular carcinoma.

Authors:  Ya Cheng; Song-Ge Xing; Wei-Dong Jia; Mei Huang; Na-Na Bian
Journal:  Onco Targets Ther       Date:  2016-12-19       Impact factor: 4.147

Review 6.  Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma.

Authors:  Ana B Herrero; Elizabeta A Rojas; Irena Misiewicz-Krzeminska; Patryk Krzeminski; Norma C Gutiérrez
Journal:  Int J Mol Sci       Date:  2016-11-30       Impact factor: 5.923

7.  PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy.

Authors:  Xiwen Liao; Chuangye Han; Wei Qin; Xiaoguang Liu; Long Yu; Guangzhi Zhu; Tingdong Yu; Sicong Lu; Hao Su; Zhen Liu; Zhiwei Chen; Chengkun Yang; Ketuan Huang; Zhengtao Liu; Yu Liang; Jianlu Huang; Jiahong Dong; Lequn Li; Xue Qin; Xinping Ye; Kaiyin Xiao; Minhao Peng; Tao Peng
Journal:  Oncotarget       Date:  2017-04-25

Review 8.  The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression.

Authors:  Anna Tyutyunnykova; Gennady Telegeev; Anna Dubrovska
Journal:  J Cancer       Date:  2017-02-25       Impact factor: 4.207

9.  Knockdown of Phospholipase Cε (PLCε) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer.

Authors:  Xiao Wang; Yanru Fan; Zhongbo Du; Jiaxin Fan; Yanni Hao; Jinhua Wang; Xiaohou Wu; Chunli Luo
Journal:  Med Sci Monit       Date:  2018-01-13

10.  MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma.

Authors:  Xiao-Bin Cui; Hao Peng; Ran-Ran Li; Jian-Qin Mu; Lan Yang; Na Li; Chun-Xia Liu; Jian-Ming Hu; Shu-Gang Li; Yutao Wei; Hong Zhou; Feng Li; Yun-Zhao Chen
Journal:  Oncotarget       Date:  2017-09-27
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