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Literature DB >> 24762652

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases.

Wu-Lin Charng¹, Shinya Yamamoto², Hugo J Bellen³.

Abstract

Signaling pathways and cellular processes that regulate neural development are used post-developmentally for proper function and maintenance of the nervous system. Genes that have been studied in the context of the development of Drosophila peripheral nervous system (PNS) and neuromuscular junction (NMJ) have been identified as players in the pathogenesis of human neurodegenerative diseases, including spinocerebellar ataxia, amyotrophic lateral sclerosis, and spinal muscular atrophy. Hence, by unraveling the molecular mechanisms that underlie proneural induction, cell fate determination, axonal targeting, dendritic branching, and synapse formation in Drosophila, novel features related to these disorders have been revealed. In this review, we summarize and discuss how studies of Drosophila PNS and NMJ development have provided guidance in experimental approaches for these diseases.

Entities: Chemical

Mesh：

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Year: 2014 PMID： 24762652 PMCID： PMC4122633 DOI： 10.1016/j.conb.2014.03.001

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

65 in total

1. Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.

Authors: Sung Min Han; Hiroshi Tsuda; Youfeng Yang; Jack Vibbert; Pauline Cottee; Se-Jin Lee; Jessica Winek; Claire Haueter; Hugo J Bellen; Michael A Miller
Journal: Dev Cell Date: 2012-01-19 Impact factor: 12.270

Review 2. Notch and disease: a growing field.

Authors: Angeliki Louvi; Spyros Artavanis-Tsakonas
Journal: Semin Cell Dev Biol Date: 2012-02-20 Impact factor: 7.727

3. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Authors: Manuela Neumann; Deepak M Sampathu; Linda K Kwong; Adam C Truax; Matthew C Micsenyi; Thomas T Chou; Jennifer Bruce; Theresa Schuck; Murray Grossman; Christopher M Clark; Leo F McCluskey; Bruce L Miller; Eliezer Masliah; Ian R Mackenzie; Howard Feldman; Wolfgang Feiden; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Journal: Science Date: 2006-10-06 Impact factor: 47.728

4. Atonal is the proneural gene for Drosophila photoreceptors.

Authors: A P Jarman; E H Grell; L Ackerman; L Y Jan; Y N Jan
Journal: Nature Date: 1994-06-02 Impact factor: 49.962

5. Calmodulin and profilin coregulate axon outgrowth in Drosophila.

Authors: Y S Kim; S Furman; H Sink; M F VanBerkum
Journal: J Neurobiol Date: 2001-04

6. The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila.

Authors: Zhaodong Li; Yubing Lu; Xia-Lian Xu; Fen-Biao Gao
Journal: Hum Mol Genet Date: 2012-10-05 Impact factor: 6.150

7. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.

Authors: Agnes L Nishimura; Miguel Mitne-Neto; Helga C A Silva; Antônio Richieri-Costa; Susan Middleton; Duilio Cascio; Fernando Kok; João R M Oliveira; Tom Gillingwater; Jeanette Webb; Paul Skehel; Mayana Zatz
Journal: Am J Hum Genet Date: 2004-09-15 Impact factor: 11.025

Review 8. Receptor tyrosine kinases in Drosophila development.

Authors: Richelle Sopko; Norbert Perrimon
Journal: Cold Spring Harb Perspect Biol Date: 2013-06-01 Impact factor: 10.005

9. Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.

Authors: Niko Hensel; Andreas Ratzka; Hella Brinkmann; Lars Klimaschewski; Claudia Grothe; Peter Claus
Journal: PLoS One Date: 2012-02-13 Impact factor: 3.240

10. Modeling spinal muscular atrophy in Drosophila.

Authors: Howard Chia-Hao Chang; Douglas N Dimlich; Takakazu Yokokura; Ashim Mukherjee; Mark W Kankel; Anindya Sen; Vasanthi Sridhar; Tudor A Fulga; Anne C Hart; David Van Vactor; Spyros Artavanis-Tsakonas
Journal: PLoS One Date: 2008-09-15 Impact factor: 3.240

13 in total

Review 1. Making sense out of missense mutations: Mechanistic dissection of Notch receptors through structure-function studies in Drosophila.

Authors: Shinya Yamamoto
Journal: Dev Growth Differ Date: 2020-01-13 Impact factor: 2.053

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases.

1. Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.

Review 2. Notch and disease: a growing field.

3. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

4. Atonal is the proneural gene for Drosophila photoreceptors.

5. Calmodulin and profilin coregulate axon outgrowth in Drosophila.

6. The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila.

7. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.

Review 8. Receptor tyrosine kinases in Drosophila development.

9. Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.

10. Modeling spinal muscular atrophy in Drosophila.

Review 1. Making sense out of missense mutations: Mechanistic dissection of Notch receptors through structure-function studies in Drosophila.

2. Novel Functional Properties of Drosophila CNS Glutamate Receptors.

Review 3. Die in pieces: How Drosophila sheds light on neurite degeneration and clearance.

4. γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor.

5. Epigenetic mechanisms modulate differences in Drosophila foraging behavior.

Review 6. Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen in Drosophila.

7. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila.

Review 8. Drosophila tools and assays for the study of human diseases.

9. DISC1 causes associative memory and neurodevelopmental defects in fruit flies.

10. Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses.