OBJECTIVE: To identify the relationship between glycemic indices and β cell function in patients with newly diagnosed type 2 diabetes. METHODS: The cross-sectional analysis included 61 patients with newly diagnosed type 2 diabetes who received continuous glucose monitoring (CGM) for 72 hours. The association between β cell function and glycemic indices including A1C and glycemic variability was investigated. RESULTS: A1C (r = -0.405, p = 0.001) and standard deviation of blood glucose (SDBG, r = -0.274, p = 0.032) were significantly correlated to HOMA-β cell function (HBCI), whereas mean amplitude of glycemic excursions (MAGE, r = -0.210, p = 0.104) was not informative. After multiple confounders adjustments, A1C (β = -7.35, p < 0.001), MAGE (β = -4.64, p = 0.040), and SDBG (β = -12.3, p = 0.012) were associated with HBCI. CONCLUSION: A1C and glycemic variability were both associated with β cell function in patients with newly diagnosed type 2 diabetes. The main limitations of the present study are the cross-sectional design in nature and the limited sample size.
OBJECTIVE: To identify the relationship between glycemic indices and β cell function in patients with newly diagnosed type 2 diabetes. METHODS: The cross-sectional analysis included 61 patients with newly diagnosed type 2 diabetes who received continuous glucose monitoring (CGM) for 72 hours. The association between β cell function and glycemic indices including A1C and glycemic variability was investigated. RESULTS:A1C (r = -0.405, p = 0.001) and standard deviation of blood glucose (SDBG, r = -0.274, p = 0.032) were significantly correlated to HOMA-β cell function (HBCI), whereas mean amplitude of glycemic excursions (MAGE, r = -0.210, p = 0.104) was not informative. After multiple confounders adjustments, A1C (β = -7.35, p < 0.001), MAGE (β = -4.64, p = 0.040), and SDBG (β = -12.3, p = 0.012) were associated with HBCI. CONCLUSION:A1C and glycemic variability were both associated with β cell function in patients with newly diagnosed type 2 diabetes. The main limitations of the present study are the cross-sectional design in nature and the limited sample size.
Entities:
Keywords:
Glycated hemoglobin; Glycemic variability; Type 2 diabetes