Susan M Webb1, John E Ware2, Anna Forsythe1, Min Yang3, Xavier Badia1, Lauren M Nelson1, James E Signorovitch1, Lori McLeod1, Mario Maldonado1, Wojciech Zgliczynski1, Christophe de Block1, Lesly Portocarrero-Ortiz1, Monica Gadelha1. 1. Department of Medicine/EndocrinologyCentre for Biomedical Research on Rare Diseases (CIBERER Unit 747), Hospital Sant Pau, Universitat Autònoma de Barcelona, Barcelona, SpainDepartment of Quantitative Health SciencesUniversity of Massachusetts Medical School, Worcester, Massachusetts, USAJohn Ware Research GroupInc., Worcester, Massachusetts, USANovartis Pharmaceuticals CorporationEast Hanover, New Jersey, USAAnalysis GroupInc., Boston, Massachusetts, USAIMS HealthBarcelona, SpainRTI Health SolutionsResearch Triangle Park, North Carolina, USANovartis Pharma AGBasel, SwitzerlandDepartment of EndocrinologyCentre for Postgraduate Medical Education, Warsaw, PolandDepartment of EndocrinologyDiabetology and Metabolism, University Hospital, Antwerp, BelgiumNational Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez'Mexico City, MexicoDivision of EndocrinologyMedical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 2. Department of Medicine/EndocrinologyCentre for Biomedical Research on Rare Diseases (CIBERER Unit 747), Hospital Sant Pau, Universitat Autònoma de Barcelona, Barcelona, SpainDepartment of Quantitative Health SciencesUniversity of Massachusetts Medical School, Worcester, Massachusetts, USAJohn Ware Research GroupInc., Worcester, Massachusetts, USANovartis Pharmaceuticals CorporationEast Hanover, New Jersey, USAAnalysis GroupInc., Boston, Massachusetts, USAIMS HealthBarcelona, SpainRTI Health SolutionsResearch Triangle Park, North Carolina, USANovartis Pharma AGBasel, SwitzerlandDepartment of EndocrinologyCentre for Postgraduate Medical Education, Warsaw, PolandDepartment of EndocrinologyDiabetology and Metabolism, University Hospital, Antwerp, BelgiumNational Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez'Mexico City, MexicoDivision of EndocrinologyMedical School, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilDepartment of Medicine/EndocrinologyCentre for Biomedical Research on Rare Diseases (CIBERER Unit 747), Hospital Sant Pau, Universitat Autònoma de Barcelona, Barcelona, SpainDepartment of Quantitative Health SciencesUniversity of Massachusetts Medical School, Worcester, Massachusetts, USAJohn Ware Research GroupInc., Worcester, Massachusetts, USANovartis Pharmaceuticals CorporationEast Hanover, New Jersey, USAAnalysis GroupInc., Boston, Massachusetts, USAIMS HealthBarcelona, SpainRTI Health SolutionsResearch Triangle Park, North Carolina, USANovartis Pharma AGBasel, SwitzerlandDepartment of EndocrinologyCentre for Postgraduate Medical Education, Warsaw, PolandDepartment of EndocrinologyDiabetology and Metabolism, University Hospital, Antwerp, BelgiumNational Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez'Mexico City, MexicoDivision of EndocrinologyMedical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 3. Department of Medicine/EndocrinologyCentre for Biomedical Research on Rare Diseases (CIBERER Unit 747), Hospital Sant Pau, Universitat Autònoma de Barcelona, Barcelona, SpainDepartment of Quantitative Health SciencesUniversity of Massachusetts Medical School, Worcester, Massachusetts, USAJohn Ware Research GroupInc., Worcester, Massachusetts, USANovartis Pharmaceuticals CorporationEast Hanover, New Jersey, USAAnalysis GroupInc., Boston, Massachusetts, USAIMS HealthBarcelona, SpainRTI Health SolutionsResearch Triangle Park, North Carolina, USANovartis Pharma AGBasel, SwitzerlandDepartment of EndocrinologyCentre for Postgraduate Medical Education, Warsaw, PolandDepartment of EndocrinologyDiabetology and Metabolism, University Hospital, Antwerp, BelgiumNational Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez'Mexico City, MexicoDivision of EndocrinologyMedical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil myang@analysisgroup.com.
Abstract
OBJECTIVE: Cushing's disease (CD) can significantly impair patients' health-related quality of life (HRQOL). This study investigated the treatment effectiveness of pasireotide on HRQOL of CD patients, and assessed the relationships between HRQOL and urinary free cortisol (UFC) and CD-related signs and symptoms. DESIGN: In this phase III, randomized, double-blind study, patients with UFC ≥1.5×upper limit of normal (ULN) received s.c. pasireotide 600 or 900 μg twice daily. The trial primary endpoint was UFC at or below ULN at month 6 without dose titration. Open-label treatment continued through month 12. HRQOL was measured using the Cushing's Quality of Life Questionnaire (CushingQoL) instrument at baseline and follow-up visits until month 12 during which clinical signs and features of CD, and the Beck Depression Inventory II (BDI-II), were also collected. METHODS: Pearson's/Spearman's correlations between changes in CushingQoL and changes in clinical signs and symptoms were assessed. Changes in CushingQoL and the proportion of patients achieving a clinically meaningful improvement in CushingQoL were also compared among patients stratified by mean UFC (mUFC) control status (controlled, partially controlled, and uncontrolled) at month 6. Analyses were also conducted at month 12, with multivariable adjustment for baseline characteristics and CushingQoL. RESULTS:Change in CushingQoL was significantly correlated with changes in mUFC (r=-0.40), BMI (r=-0.39), weight (r=-0.41), and BDI-II (r=-0.54) at month 12 but not at month 6. The percentage of CushingQoL responders at month 12 based on month 6 mUFC control status were as follows: 63, 58.8, and 37.9% in the controlled, partially controlled, and uncontrolled groups respectively. Adjusted CushingQoL scores at month 12 were 58.3 for controlled patients (Δ=11.5 vs uncontrolled, P=0.012) and 54.5 for partially controlled patients (Δ=7.7 vs uncontrolled, P=0.170). CONCLUSIONS:Pasireotide treatment can result in a meaningful HRQOL improvement among those who complete a 12-month treatment period, most often among patients achieving biochemical control.
RCT Entities:
OBJECTIVE:Cushing's disease (CD) can significantly impair patients' health-related quality of life (HRQOL). This study investigated the treatment effectiveness of pasireotide on HRQOL of CDpatients, and assessed the relationships between HRQOL and urinary free cortisol (UFC) and CD-related signs and symptoms. DESIGN: In this phase III, randomized, double-blind study, patients with UFC ≥1.5×upper limit of normal (ULN) received s.c. pasireotide 600 or 900 μg twice daily. The trial primary endpoint was UFC at or below ULN at month 6 without dose titration. Open-label treatment continued through month 12. HRQOL was measured using the Cushing's Quality of Life Questionnaire (CushingQoL) instrument at baseline and follow-up visits until month 12 during which clinical signs and features of CD, and the Beck Depression Inventory II (BDI-II), were also collected. METHODS: Pearson's/Spearman's correlations between changes in CushingQoL and changes in clinical signs and symptoms were assessed. Changes in CushingQoL and the proportion of patients achieving a clinically meaningful improvement in CushingQoL were also compared among patients stratified by mean UFC (mUFC) control status (controlled, partially controlled, and uncontrolled) at month 6. Analyses were also conducted at month 12, with multivariable adjustment for baseline characteristics and CushingQoL. RESULTS: Change in CushingQoL was significantly correlated with changes in mUFC (r=-0.40), BMI (r=-0.39), weight (r=-0.41), and BDI-II (r=-0.54) at month 12 but not at month 6. The percentage of CushingQoL responders at month 12 based on month 6 mUFC control status were as follows: 63, 58.8, and 37.9% in the controlled, partially controlled, and uncontrolled groups respectively. Adjusted CushingQoL scores at month 12 were 58.3 for controlled patients (Δ=11.5 vs uncontrolled, P=0.012) and 54.5 for partially controlled patients (Δ=7.7 vs uncontrolled, P=0.170). CONCLUSIONS: Pasireotide treatment can result in a meaningful HRQOL improvement among those who complete a 12-month treatment period, most often among patients achieving biochemical control.