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Literature DB >> 24759824

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.

Jori Symons¹, Linos Vandekerckhove², Gero Hütter³, Annemarie M J Wensing¹, Petra M van Ham¹, Steven G Deeks⁴, Monique Nijhuis¹.

Abstract

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.

Entities: Disease Gene Species

Keywords: Berlin-Patient; HIV; coreceptor; cure; stem cell transplantation

Mesh：

Substances：

Year: 2014 PMID： 24759824 PMCID： PMC4990826 DOI： 10.1093/cid/ciu284

Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079

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Authors: Y Isaka; A Sato; S Miki; S Kawauchi; H Sakaida; T Hori; T Uchiyama; A Adachi; M Hayami; T Fujiwara; O Yoshie
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