Literature DB >> 24757332

Influence of mevinolin on chloroplast terpenoids in Cannabis sativa.

Hakimeh Mansouri1, Fatemeh Salari1.   

Abstract

Plants synthesize a myriad of isoprenoid products that are required both for essential constitutive processes and for adaptive responses to the environment. Two independent pathways for the biosynthesis of isoprenoid precursors coexist within the plant cell: the cytosolic mevalonic acid (MVA) pathway and the plastidial methylerythritol phosphate (MEP) pathway. In this study, we investigated the inhibitory effect of the MVA pathway on isoprenoid biosynthesized by the MEP pathway in Cannabis sativa by treatment with mevinolin. The amount of chlorophyll a, b, and total showed to be significantly enhanced in treated plants in comparison with control plants. Also, mevinolin induced the accumulation of carotenoids and α-tocopherol in treated plants. Mevinolin caused a significant decrease in tetrahydrocannabinol (THC) content. This result show that the inhibition of the MVA pathway stimulates MEP pathway but none for all metabolites.

Entities:  

Keywords:  Cannabinoids; Cannabis sativa; Mevinolin; Terpenoids

Year:  2014        PMID： 24757332      PMCID： PMC3988329          DOI： 10.1007/s12298-014-0222-x

Source DB:  PubMed          Journal:  Physiol Mol Biol Plants        ISSN： 0974-0430


  9 in total

1.  Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses.

Authors:  M Fellermeier; W Eisenreich; A Bacher; M H Zenk
Journal:  Eur J Biochem       Date:  2001-03

2.  1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants.

Authors:  J M Estévez; A Cantero; A Reindl; S Reichler; P León
Journal:  J Biol Chem       Date:  2001-03-22       Impact factor: 5.157

3.  Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells.

Authors:  Andréa Hemmerlin; Jean-François Hoeffler; Odile Meyer; Denis Tritsch; Isabelle A Kagan; Catherine Grosdemange-Billiard; Michel Rohmer; Thomas J Bach
Journal:  J Biol Chem       Date:  2003-05-07       Impact factor: 5.157

4.  Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis.

Authors:  Hiroyuki Kasahara; Atsushi Hanada; Tomohisa Kuzuyama; Motoki Takagi; Yuji Kamiya; Shinjiro Yamaguchi
Journal:  J Biol Chem       Date:  2002-09-12       Impact factor: 5.157

5.  Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.

Authors:  Manuel Rodríguez-Concepción; Oriol Forés; Jaime F Martinez-García; Victor González; Michael A Phillips; Albert Ferrer; Albert Boronat
Journal:  Plant Cell       Date:  2003-12-05       Impact factor: 11.277

6.  Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.

Authors:  Scott E Sattler; Edgar B Cahoon; Sean J Coughlan; Dean DellaPenna
Journal:  Plant Physiol       Date:  2003-08       Impact factor: 8.340

7.  Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway.

Authors:  Noriko Nagata; Masashi Suzuki; Shigeo Yoshida; Toshiya Muranaka
Journal:  Planta       Date:  2002-09-17       Impact factor: 4.116

8.  Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana.

Authors:  Oliver Laule; Andreas Fürholz; Hur-Song Chang; Tong Zhu; Xun Wang; Peter B Heifetz; Wilhelm Gruissem; Markus Lange
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-14       Impact factor: 11.205

9.  Normal phase high-performance liquid chromatography method for the determination of tocopherols and tocotrienols in cereals.

Authors:  Gianfranco Panfili; Alessandra Fratianni; Mario Irano
Journal:  J Agric Food Chem       Date:  2003-07-02       Impact factor: 5.279
  9 in total
  4 in total

1.  Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.

Authors:  Bahtijor Rasulov; Eero Talts; Astrid Kännaste; Ülo Niinemets
Journal:  Plant Physiol       Date:  2015-04-29       Impact factor: 8.340

2.  A Geranylfarnesyl Diphosphate Synthase Provides the Precursor for Sesterterpenoid (C25) Formation in the Glandular Trichomes of the Mint Species Leucosceptrum canum.

Authors:  Yan Liu; Shi-Hong Luo; Axel Schmidt; Guo-Dong Wang; Gui-Ling Sun; Marcus Grant; Ce Kuang; Min-Jie Yang; Shu-Xi Jing; Chun-Huan Li; Bernd Schneider; Jonathan Gershenzon; Sheng-Hong Li
Journal:  Plant Cell       Date:  2016-03-03       Impact factor: 11.277

Review 3.  Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield.

Authors:  Rachel Backer; Timothy Schwinghamer; Phillip Rosenbaum; Vincent McCarty; Samuel Eichhorn Bilodeau; Dongmei Lyu; Md Bulbul Ahmed; George Robinson; Mark Lefsrud; Olivia Wilkins; Donald L Smith
Journal:  Front Plant Sci       Date:  2019-04-24       Impact factor: 5.753

4.  Editorial: Cannabis Genomics, Breeding and Production.

Authors:  Rachel Backer; Giuseppe Mandolino; Olivia Wilkins; Mahmoud A ElSohly; Donald L Smith
Journal:  Front Plant Sci       Date:  2020-10-30       Impact factor: 5.753
  4 in total

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