A case of systemic cryptococcal disease in HIV infection.

Globally, Cryptococcosis is the most common invasive mycosis in HIV disease. Incidence rates vary widely by geographical region and resource availability and reportedly range from 0.04 to 12% per year (1). Sub-Saharan Africa accounts for the greatest burden with a median incidence of 3.2% per year (1). Since the advent of widespread use of antiretroviral therapy (ART), incidence rates of opportunistic infections have been significantly declining (2).