| Literature DB >> 24756377 |
Ku Jung Kwon1, Seunghee Bae1, Karam Kim1, In Sook An1, Kyu Joong Ahn2, Sungkwan An1, Hwa Jun Cha1.
Abstract
Melanogenesis is the process of generating pigmentation via melanin synthesis and delivery. Three key enzymes, tyrosinase, tyrosinase-related protein 1 (TRP1) and TRP2, metabolize melanin from L-tyrosine. Melanin synthesizing enzymes are regulated by microphthalmia-associated transcription factor (MITF). The titrated extract of Centella asiatica (TECA) contains the major components asiatic acid, asiaticoside and madecassic acid. The present study revealed that TECA reduces the melanin content in melanocytes. Moreover, the asiaticoside contained in TECA modulated melanogenesis by inhibiting tyrosinase mRNA expression. The decrease in tyrosinase mRNA levels was mediated through MITF. Uniquely, asiaticoside inhibited MITF by decreasing its DNA binding affinity. In conclusion, the results of the present study indicate that asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening.Entities:
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Year: 2014 PMID： 24756377 DOI： 10.3892/mmr.2014.2159
Source DB: PubMed Journal: Mol Med Rep ISSN： 1791-2997 Impact factor: 2.952