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Literature DB >> 24755719

Searching for the mechanism(s) of ECT's therapeutic effect.

W Vaughn McCall¹, Chittaranjan Andrade, Pascal Sienaert.

Abstract

The exact therapeutic mechanism of action of electroconvulsive therapy (ECT) remains unresolved. Numerous psychological theories from decades ago have been proven untrue. In the ensuing years, ECT has been proven to have numerous reproducible effects on brain chemistry, regional brain activity, electroencephalographic sleep stages, and neurogenesis. Clinically, ECT has been shown to have antidepressant, antipsychotic, antimanic, antiparkinsonian, and anticonvulsive effects. It is possible that different biological effects of ECT are responsible for different clinical effects or that several biological effects in concert work together to produce a given clinical effect. This paper comments on the array of possible mechanisms and points toward the future of mechanistic research in ECT.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2014 PMID： 24755719 PMCID： PMC4695970 DOI： 10.1097/YCT.0000000000000121

Source DB: PubMed Journal: J ECT ISSN： 1095-0680 Impact factor: 3.635

39 in total

Review 1. The effectiveness of electroconvulsive therapy: a literature review.

Authors: John Read; Richard Bentall
Journal: Epidemiol Psichiatr Soc Date: 2010 Oct-Dec

2. Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia.

Authors: Chittaranjan Andrade; Shahid Ahmad Shaikh; Lakshmy Narayan; Christine Blasey; Joseph Belanoff
Journal: J Neural Transm (Vienna) Date: 2011-09-16 Impact factor: 3.575

3. There's more to placebo-related improvement than the placebo effect alone.

Authors: Chittaranjan Andrade
Journal: J Clin Psychiatry Date: 2012-10 Impact factor: 4.384

4. 24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment.

Authors: P Linkowski; J Mendlewicz; M Kerkhofs; R Leclercq; J Golstein; M Brasseur; G Copinschi; E Van Cauter
Journal: J Clin Endocrinol Metab Date: 1987-07 Impact factor: 5.958

5. Images in electroconvulsive therapy: electroconvulsive shocks dose-dependently increase dendritic arborization in the CA1 region of the rat hippocampus.

Authors: Jangama S M Smitha; Ravindranath Roopa; Nagarchi Khaleel; Bindu M Kutty; Chittaranjan Andrade
Journal: J ECT Date: 2014-09 Impact factor: 3.635

6. Images in electroconvulsive therapy: ECS dose-dependently increases cell proliferation in the subgranular region of the rat hippocampus.

Authors: Jangama S M Smitha; Ravindranath Roopa; B K Chandrasekhar Sagar; Bindu M Kutty; Chittaranjan Andrade
Journal: J ECT Date: 2014-09 Impact factor: 3.635

7. Poor health-related quality of life prior to ECT in depressed patients normalizes with sustained remission after ECT.

Authors: W Vaughn McCall; David Reboussin; Joan Prudic; Roger F Haskett; Keith Isenberg; Mark Olfson; Peter B Rosenquist; Harold A Sackeim
Journal: J Affect Disord Date: 2012-11-15 Impact factor: 4.839

8. Randomized comparison of ultra-brief bifrontal and unilateral electroconvulsive therapy for major depression: cognitive side-effects.

Authors: P Sienaert; K Vansteelandt; K Demyttenaere; J Peuskens
Journal: J Affect Disord Date: 2009-07-05 Impact factor: 4.839

3. Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression.

Authors: Serkan Zincir; Pelin Öztürk; Ali Emrah Bilgen; Filiz İzci; Cihad Yükselir
Journal: Neuropsychiatr Dis Treat Date: 2016-06-15 Impact factor: 2.570

3 in total