Literature DB >> 2475527

Critical evaluation of monoclonal antibody staining in breast carcinoma.

D M Parham1, G Coghill, A J Robertson.   

Abstract

The immunoperoxidase staining of 84 primary invasive breast carcinomas with four monoclonal antibodies (BRST-1, HMFG1, EMA, B72.3) was evaluated by semiquantitative light microscopical examination and quantitative image analysis. Major differences in the staining of the tumours for each of the monoclonal antibodies was observed. Correlation between monoclonal antibody staining and patient age, survival, histological grade, tumour diameter and cellularity was also carried out. This showed a significant association between histological grade and staining with BRST-1 and EMA.

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Year:  1989        PMID： 2475527      PMCID： PMC1142056          DOI： 10.1136/jcp.42.8.810

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  25 in total

1.  Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.

Authors:  J Burchell; H Durbin; J Taylor-Papadimitriou
Journal:  J Immunol       Date:  1983-07       Impact factor: 5.422

2.  Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions.

Authors:  A A Epenetos; G Canti; J Taylor-Papadimitriou; M Curling; W F Bodmer
Journal:  Lancet       Date:  1982-11-06       Impact factor: 79.321

3.  A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations.

Authors:  M Nuti; Y A Teramoto; R Mariani-Costantini; P H Hand; D Colcher; J Schlom
Journal:  Int J Cancer       Date:  1982-05-15       Impact factor: 7.396

4.  A monoclonal antibody, NCRC-11, raised to human breast carcinoma. 1. Production and immunohistological characterization.

Authors:  I O Ellis; R A Robins; C W Elston; R W Blamey; B Ferry; R W Baldwin
Journal:  Histopathology       Date:  1984-05       Impact factor: 5.087

5.  The prognostic significance of two epithelial membrane antigens expressed by human mammary carcinomas.

Authors:  M J Wilkinson; A Howell; M Harris; J Taylor-Papadimitriou; R Swindell; R A Sellwood
Journal:  Int J Cancer       Date:  1984-03-15       Impact factor: 7.396

6.  An assessment of the value of epithelial membrane antigen and other epithelial markers in solving diagnostic problems in tumour histopathology.

Authors:  J P Sloane; F Hughes; M G Ormerod
Journal:  Histochem J       Date:  1983-07

7.  Use of antisera to epithelial membrane antigen for the cytodiagnosis of malignancy in serous effusions.

Authors:  A To; D V Coleman; D P Dearnaley; M G Ormerod; K Steele; A M Neville
Journal:  J Clin Pathol       Date:  1981-12       Impact factor: 3.411

8.  Epithelial membrane antigen: partial purification, assay and properties.

Authors:  M G Ormerod; K Steele; J H Westwood; M N Mazzini
Journal:  Br J Cancer       Date:  1983-10       Impact factor: 7.640

9.  Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen.

Authors:  D P Dearnaley; J P Sloane; M G Ormerod; K Steele; R C Coombes; H M Clink; T J Powles; H T Ford; J C Gazet; A M Neville
Journal:  Br J Cancer       Date:  1981-07       Impact factor: 7.640

10.  Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.

Authors:  H J BLOOM; W W RICHARDSON
Journal:  Br J Cancer       Date:  1957-09       Impact factor: 7.640
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