Literature DB >> 2475520

Anti-SM and anti-U1-RNP lupus antibody fine specificities.

A M Francoeur1.   

Abstract

Evidence for the presence of multiple shared epitopes on the target cellular antigens was found when 290 anti-Sm and anti-U1-RNP lupus sera were analyzed by immunoblotting. Forty-eight different immunoblot patterns were observed with the sera. Studies with selected antigen-affinity-purified antibodies confirmed the presence of multiple shared epitopes, in agreement with findings obtained with monoclonal antibodies. The results have implications for the design of effective diagnostics and for the use of these antibodies as molecular probes.

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Year:  1989        PMID： 2475520     DOI： 10.1007/bf00916822

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  27 in total

1.  The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.

Authors:  R A Spritz; K Strunk; C S Surowy; S O Hoch; D E Barton; U Francke
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

2.  Murine lupus monoclonal antibodies define five epitopes on two different Sm polypeptides.

Authors:  D G Williams; M R Stocks; P R Smith; R N Maini
Journal:  Immunology       Date:  1986-07       Impact factor: 7.397

3.  The use of immunoblotting and immunoprecipitation of (U) small nuclear ribonucleoproteins in the analysis of sera of patients with mixed connective tissue disease and systemic lupus erythematosus. A cross-sectional, longitudinal study.

Authors:  I Pettersson; G Wang; E I Smith; H Wigzell; E Hedfors; J Horn; G C Sharp
Journal:  Arthritis Rheum       Date:  1986-08

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

Authors:  T Mimori; J A Hardin; J A Steitz
Journal:  J Biol Chem       Date:  1986-02-15       Impact factor: 5.157

Review 6.  Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.

Authors:  E M Tan
Journal:  Adv Immunol       Date:  1982       Impact factor: 3.543

7.  Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus.

Authors:  M R Lerner; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

Review 8.  Autoantibodies reactive with small ribonucleoprotein antigens: a convergence of molecular biology and clinical immunology.

Authors:  L J McNeilage; S Whittingham; I R Mackay
Journal:  J Clin Lab Immunol       Date:  1984-09

9.  Distribution of the 70K U1 RNA-associated protein during interphase and mitosis. Correlation with other U RNP particles and proteins of the nuclear matrix.

Authors:  R Verheijen; H Kuijpers; P Vooijs; W Van Venrooij; F Ramaekers
Journal:  J Cell Sci       Date:  1986-12       Impact factor: 5.285

10.  Protein antigens of the RNA-protein complexes detected by anti-SM and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders.

Authors:  G E Conner; D Nelson; R Wisniewolski; R G Lahita; G Blobel; H G Kunkel
Journal:  J Exp Med       Date:  1982-11-01       Impact factor: 14.307
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  4 in total

Review 1.  B-cell epitopes of Sm autoantigens.

Authors:  L A Rokeach; S O Hoch
Journal:  Mol Biol Rep       Date:  1992-06       Impact factor: 2.316

2.  Analysis of autoantibody specificities in selected systemic lupus erythematosus (SLE) sera.

Authors:  A M Francoeur
Journal:  J Clin Immunol       Date:  1989-05       Impact factor: 8.317

3.  Multiple overlapping homologies between two rheumatoid antigens and immunosuppressive viruses.

Authors:  A Douvas; S Sobelman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

4.  Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.

Authors:  M Satoh; J J Langdon; K J Hamilton; H B Richards; D Panka; R A Eisenberg; W H Reeves
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808
  4 in total

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